Pharm of Sex hormones Flashcards
when would you use oestrogen in children?
hypogonadism
where do all the sex hormones come from biochemically?
cholesterol
where does oestrogen act at a receptor level?
nuclear. Sometimes membrane in rapid effect
main use of Tamoxifen? what is it
Palliative treatment of metastatic breast cancer. partial agonist
how do aromatase inhibitors work?
block synthesis of oestrogen from testosterone. Also block the conversion of a pre-testosterone to a dif oestrogen.
what converts testosterone to dihydrotestosterone?
5a reductase
two main functions of testosterone use
androgenic and anabolic
Adverse effects of Androgens? (give 2 for males, 2 for children and 1 for athletes)
Increase LDL & decrease HDL(increase risk of coronary heart disease). Priapism.
Kids = Premature closure of epiphyseal plates or abnormal sexual maturation.
Athletes = Liver damage
what class is Cyproterone? what is its main use
steroidal antagonist for androgens. Prostate cancer
what class is FLumatide? what is it used for
Non-steroidal antagonist. Metatsatic prostate cancer
MOA of an antiandrogen that isnt an antagonist. Drug name and use?
5a reductase inhibitor - Finasteride. BPH and hair loss
why might a 5a reductase inhibitor cause breast enlargement in a male?
testosterone cant be converted to dihyro so results in more oestrogen production
what is Raloxifene?
SERM - partial agonist
what is Fulvestrant
SERM - Full agonist
which tissues in the body are oesteogen receptors and thus the related drugs (5)
breast, uterus, bone, CNS, Heart
