Lec 77 PTSD Flashcards

1
Q

What is diagnostic criteria for trauma?

A

exposure to actual or threatened death, serious injury, or sexual violence in 1 or more of the ways:

  • direct experiencing traumatic event
  • witnessing event as it occurred to others
  • learning traumatic event occurred to close family or friend
  • experiencing repeated or extreme exposure to aversive details of event
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2
Q

What are intrusion symptoms of PTSD?

A

presence of 1 or more of the following

  • recurrent + intrusive distressing memories of the event
  • recurrent distressing dreams
  • dissociative rxns [flashbacks] in which feel as if event recurring
  • intense psych distress at exposure to cues that symbolize aspects of the event
  • psych reactivity on exposure to cues related to the event
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3
Q

What are avoidance systems of PTSD?

A

persistent avoidance of stimuli associated with trauma such as:

  • avoiding distressing memories/thoughts or feelings associated with trauma
  • avoiding external reminders [activities/people/places] that arouse distressing memories thoughts or feelings about the trauma
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4
Q

What negative alterations in cognition or mood associated with PTSD?

A

2 or more of the following

  • can’t recall important aspect trauma
  • negative beliefs about oneself or others
  • distorted cognition about the cause or consequences of the trauma leading to blame self or others
  • persistent negative emotional state
  • decreased interest in activities
  • feel detached from others
  • can’t experience positive emotions
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5
Q

What alterations in arousal or reactivity associated with PTSD?

A

2 or more of the following

  • irritability or outbursts of anger
  • reckless or self destructive behavior
  • hyper-vigilance
  • exaggerated startle response
  • difficulty concentrating
  • difficulty falling or staying asleep
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6
Q

What are diagnostic criteria of PTSD?

A
  • exposure to trauma
  • intrusion symptoms
  • avoidance of stimuli associated w/ trauma
  • negative alterations in cognition or mood
  • alterations in arousal or activity
  • symptoms last > 1 month
  • causes clinically significant distress or impairment in social, occupational functioning
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7
Q

What is acute stress disorder?

A
  • exposure to traumatic event
  • presence of 9 or more symptoms from any of the following categoreies: intrusion, negative mood, dissociation [altered sense of reality], avoidance, arousal, impaired function, significant distress
  • develops within 4 wks of exposure and lasts < 1 month
  • considered a precursor to PTSD
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8
Q

How do you distinguish acute stress disorder from PTSD?

A

acute stress disorder [ASD] = dissociative symptoms [altered sense of reality, can’t recall important aspect of trauma]

symptoms last less than 1 month

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9
Q

What is course of ASD?

A

if continues is precursor to PTSD

if psychotherapy may prevent progression

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10
Q

What is epidemiology of PTSD?

A
  • ~25% of those exposed to trauma develop PTSD
  • 6.8% of US adults have PTSD , women 2x more likely than men
  • co-morbid with psych conditions MDD, anxiety disorders, substance use disorders, unexplained somatic complaints, borderline personality disorder
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11
Q

Which traumas are most likely to result in PTSD?

A
  • rape - 50%
  • combat - 38%
  • severephysical assault
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12
Q

What is course of PTSD?

A
  • 80% longer than 3 mo
  • 75% longer than 6 mo
  • 50% at least 2 yrs
  • small minority can remain symptomatic for yrs or decades
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13
Q

What are predictors of worse outcomes for PTSD?

A
  • more PTSD sx
  • comorbid med conditions
  • childhood + additional traumas
  • psych [mood, anxiety]
  • female
  • alc abuse
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14
Q

What are risk factors for PTSD?

A
  • character of individual more than type of trauma
  • trauma type, amount, severity
  • young age, women more than men, minority, low SES
  • preparedness
  • level of social support
  • perceived control
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15
Q

What is neuro model of PTSD?

A
  • stress-induced changes or inadequate adaptation of neuro systems to exposure to severe stressors
  • increase ANS responsiveness [ more NE]
  • disinhibition HPA [low cortisol –> hyperactive]
  • 5HT modulates synpathetics + HPA
  • decreased hippocampal volume, increased amygdala responsiveness, impaired mPFC

net effect –> enhanced encoding of traumatic memories, failures of habituation –> state of perpetual fear

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16
Q

What is thought to cause PTSD?

A

failure to recover from a traumatic event

17
Q

How does HPA axis dysfunction differ in PTSD vs MDD?

A

MDD: more cortisol, more CRF; less sensitive to negative feedback, HPA glucocorticoid receptors are less sensitive
- DEX suppression test = no suppression

PTSD: less cortisol, more CRF; more sensitive to negative feedback, HPA glucocorticoid receptors are more sensitive
- DEX suppression test = exaggerated suppression

18
Q

What happens to sympathetic in PTSD?

A
  • hyperadrenergic symptoms [anxiety, tachycardia, increased diastolic BP]
  • abnormally high NE in both CNS and peripheral –> leads to abnormally strong emotional memory and fear conditioning
19
Q

What happens to HPA axis in PTSD?

A

less cortisol, more CRF; more sensitive to negative feedback, HPA glucocorticoid receptors are more sensitive
- DEX suppression test = exaggerated suppression

== hyperresponsive to stress and effects of cortisol

20
Q

WHat level of NE in PTSD?

A

high

21
Q

What level of cortisol in PTSD?

A

low

22
Q

What happens to 5HT modulation in PTSD?

A

dysregulated but details not really known

23
Q

What happens to neurocircuitry in PTDS?

A

brain regions altered: fear response areas –> hippocampus, amygdala, PFC areas including ACC and orbitofrontal cortex

these areas modulate response to stress

24
Q

What is treatment for PTSD?

A

SSRIs
CBT [prolonged exposure therapy]

adrenergic blockers [propanolol, clonidine], anticonvulsants, atypical antipsychotics