29/ motor control Flashcards

(30 cards)

1
Q

what are all movements produced by the skeletal musculature initiated by

A

lower motor neurons (final neurons in motor pathway)

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2
Q

spine contains central pattern generators, what do these do

A

generate complex behaviours w/o input from the brain, although the brain does influence these systems

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3
Q

simulation of what area of the brain elicits contralateral muscle movement

A

primary motor cortex

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4
Q

what are neurons found in the brain that control motor function called

A

upper motor neurons

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5
Q

how does the motor cortex somatotopic map compare to the somatosensory system map

A
  • similar but not identical
  • area dedicated to ears smaller - we don’t move our ears
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6
Q

what type of striated muscle controls: trunk movement/ shoulder, elbow, pelvis, knee/ hands, feet, digits

A
  • axial muscles
  • proximal muscles
  • distal muscles
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7
Q

how many lower alpha neurons does each muscle fibre receive input from

A

1

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8
Q

how many muscles does each lower motor neuron innervate

A

1

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9
Q

what is a motor unit

A

motor neuron and all the muscle fibres it innervates

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10
Q

motor neuron pool

A

all the motor neurons that innervate a single muscle

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11
Q

how are motor neurons organised in the spinal cord

A
  • spatially
  • motor pool for a muscle grouped in rod shaped clusters within the spinal cord extending over several vertebral segments
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12
Q

how did we find out how motor neurons are organised in the spinal cord

A
  • tracers injected into spec muscles, then transport back along motor axons to cell bodies in spinal cord
  • injection into the gastrocnemius activates dif set of motor neurons to soleus
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13
Q

what does the medio-lateral position of a motor pool refelct

A

whether its motor neurons innervate a proximal or distal muscle

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14
Q

how are motor pools organised

A
  • somatotopic
  • both medio-laterally and a-p
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15
Q

what does somatotopy in the motor cortex reflect

A

the location of upper motor neurons that innervate lower motor neurons in the spinal cord

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16
Q

what 2 inputs do lower motor neurons receive

A
  • local spinal cord inputs
  • direct inputs from upper motor neurons
17
Q

what tracts do upper motor neurons project to lower motor neurons through

A

descending tracts

18
Q

what is the corticospinal tract cst

A
  • for control of voluntary movement
  • one of the lateral pathways of the spinal cord
  • position of the cst neurons in the cortex reflects where they project to in the spinal cord
19
Q

pyramidal cells of the motor cortex project axons in the corticospinal tract

A
  • 90% of cortex is a 6 layered structure
  • main inputs to cortex are to stellate cells in layer 4
  • main outputs are from layers 3, 5 and 6
  • axons of corticospinal tract derive from large pyramidal cells in layer 5 which project down sc
20
Q

dif sets of upper motor neurons control dif functions

A
  • axons of corticospinal tract cross the midline in the pyramidal decussation in the medulla and project contralaterally in the spinal cord to synapse on laterally located lower motor neuron circuits that control distal muscles
  • cst is one of lateral pathways
21
Q

where do brainstem upper motor neurons project to

A
  • project to medial motor pools primarily concerned w postural movement
  • axons from brainstem project ipsilaterally in vestibulospinal and reticulospinal tracts
  • project medially in spinal cord
  • synapse on medially located lower motor neuron circuits that control axial muscles
  • these are ventromedial pathways
22
Q

what do motor cortex upper motor neurons do

A
  • primarily concerned w fine voluntary control of more distal structures
  • anticipation - feeds into brainstem upper motor neurons
23
Q

what tracts make up ventromedial pathway, what does it control

A
  • vestibulospinal tract: head balance and turning
  • tectospinal: orienting response
  • reticulospinal tract: antigravity reflexes
  • posture
  • mainly ipsilateral
24
Q

dif between where upper and lower neurons synapse onto

A
  • upper: lower or interneuron
  • lower: directly on muscle fibres
25
integration of postural control w voluntary movement: what happens when person lifts lever
* first muscles to contract are those in legs * anticipatory feedforward mechanism to compensate for forces that will be generated when lever is lifted
26
indirect cortical control of lower motor neurons - 2 routes
* anticipation of movement activates an indirect projection to axial muscles via _reticular formation_. movement anticipation starts in premotor area, area 6 * activation of voluntary movement direct to spinal cord via _corticospinal tract_. movement initiation then happens in primary motor cortex, area 4
27
how does mirror therapy work for phantom limb pain
* mirror neurons identified which fire both when a person acts or observes
28
motor neuron disease - ALS. symptoms
* muscle atrophy, sclerosis (scarring) of lateral spinal cord
29
motor neuron disease - neuropathology. symptoms
* can affect both upper and lower mns * lower: muscle paresis or paralysis, loss of muscle tone due to loss of stretch reflexes, severe muscle atrophy, die from lung dysfunction * upper: muscle weakness, spasticity due to increased muscle tone (stretch reflex not modulated), hyperactive reflexes, loss of fine voluntary movement, die from loss of input to bulbar muscles via corticobulbar tract * intellect not compromised
30
what could cause neurons to degenerate in als
* excitoxicity - overstimulation leads to cell death. glutamate * esp in hypoxic conditions * only drug that helps is blocker of glutamate release - short term only * 10% genetic basis -- * gene coding superoxide dismutase which has a role in removing free radicals