29.04 - the day of the Gnarklebark Flashcards

(55 cards)

1
Q

When can clozapine be used in schizophrenia?

A

Only after 2 different antipsychotics have been tried

treatment resistant

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2
Q

Risks with clozapine

A

Neutropenia and fatal agranulocytosis

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3
Q

Side effects of Clozapine

A

Sedation!
Weight Gain!

Hypersalivation
Raised triglycerides
Cardiomyopathy
DM
Lowers seizure threshold
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4
Q

How is clozapine treatment started

A

Dose needs titrating.
Check FBC weekly for 18 weeks. THen 2 weekly for a year. Then 4 weekly.

BP, pulse and weight, Temp is also checked YEARLY (physical health). Ask about smoking and alcohol

Safety netting about high fever, chills, bone aches

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5
Q

Side effects of 1st generation antipsychotics

A
EXTRAPYRAMIDAL:
Rigidity
Bradykinesia
Dystonias
Akathisia
Tardive dyskinesia

Neuroleptic Malignant syndrome

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6
Q

Describe neuroleptic malignant syndrome

A

Life threatening

Fever
Altered consciousness
Muscle rigidity
Autonomic dysfunction

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7
Q

Side effects of 2nd generation antipsychotics

A

Fewer extrapyramidal SE

Metabolic effects:
Increase appetite
Weight gain
DM
Sedation
Hypotension
Dry mouth
Constipation
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8
Q

TCAs side effects (Amitryptiline)

A

Sedation
Weight gain
Dizziness
Hypotension

NOT TERATOGENIC, HOWEVER (used in pregnancy)

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9
Q

Antidepressants in pregnancy

A

Fluoxetine most commonly prescribed

Amitryptiline is also fine, but high OD risk

NO PAROXETINE!! or SNRIs (venlafaxine, dulexitine) or MAOIs or Mirtazapine

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10
Q

How long are SSRIs used for?

A

At least 4 wks, to say that treatment has failed.

Continue for 6 months following symptom resolution

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11
Q

Withdrawal symptoms of SSRIs

A

Anxiety
Dizziness
Sleep disturbance
Nausea

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12
Q

Antidepressants in Breastfeeding

A

Imiparime and Nortriptyline are prefered

Paroxetine or Sertraline can be used

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13
Q

How is lithium started?

A

Weight and BP measured annually
Give contraception and folic acid advise.

Check levels weekly and titrate up. Once optimum dose, check every 3 months.
U and E and TFTs every 6 months

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14
Q

SE of lithium

A
GI upset
Fine tremor
Polyuria
Polydipsia
Metallic taste
Weight gain
Oedema
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15
Q

Toxic symptoms of lithium

A
Diarrhoea
Course tremor
Ataxia
Dysarthria
Nystagmus
Confusion
Convulsions

AKI

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16
Q

Which is the only mood stabiliser that can be used in pregancy

A

Lithium
NOT in breastfeeding

still teratogenic, but less than carbamazepine or sodium valproate

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17
Q

which mood stabiliser may be used in breastfeeding

A

lamotrigine in low dose

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18
Q

Common symptoms of social phobia

A

Blushing or shaking
Fear of vomiting
Urgency or fear of micturition

Marked feature of being the focus of attention, embarrassment or humiliation.
Restricted to fearful situations.
AVOIDANCE

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19
Q

Questions To distinguish OCD from schizophrenia

A

Thoughts are acknowledged as excessive/unreasonable

NOT due to thought insertion
Compulsions originate in the mind of the patientand are not imposed by outside persons or influences

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20
Q

Medications for anxiety

A

All anti-depressants are anxiolytics (brief increase initially)

Beta blockers for autonomic symptoms: HR, sweating etc

Lorazepam has a short half-life
Diazepam has a long
<4 weeks due to addictive nature

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21
Q

What is an acute stress reaction

A

<1month after stressful even

For >3 days
Anxiety
Depression
Numbness
Detachment
Derealisation
Insomnia
Restlessness
Anger

Alcohol/drug abuse?

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22
Q

Management of acute stress reaction

A

Reduce emotional response: talk to friends/family/professionals

Encourage recall to debrief

Teach coping skills

Anxiolytics only used if severe anxiety

Hypnotics if sleep distubrance

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23
Q

What is adjustment disorder

A

Psychological reaction to new circumstances

Within 3 months
Proportionate

Anxiety/depression
Irritable
Dramatic?
Aggressive?

Sometimes autonomic arousal

Social functioning is impaired

Usually lasts couple of months

24
Q

Management of Adjustment disorder

A

Support groups to accept change
Prevent avoidance and denial

Encourage problem solving
Encourage talk/express feelings
Consider therapy

25
3 core symptoms of PTSD
Hyperarousal: persistent anxiety, irritability, insomnia, poor concentration Re-experiencing: flashbacks Avoidance: numbness, loss of interest in activities, avoiding reminders These symptoms persist beyond 6 MONTHS after event Substance abuse and guilt common Can also occur years later, if reactivation
26
Management of PTSD
Psychoeducation Trauma focused CBT Eye movement desensitisation and Reprocessing (EMDR) Antidepressants (SSRIs) Social: family support/education Reintegration Avoid alcohol
27
Characteritics of borderline EUPD
``` Chronic empty feeling Abandonment fears Relationships are unstable and intense Suicide attempts and self-harm Occasional psychotic features (pseudohallucinations) ```
28
Impulsive EUPD
``` Lacks impusle control Outbursts of violence Sensitivity to being criticised Emotional instability Inability to plan ahead Thoughtless of consequence ```
29
Management of EUPD
Dialectical behavioral therapy Group therapies Admit if danger to self Help from seniors Mood stabilisers or antidepressants may be helpful. Antipsyhcotics for agitation
30
Types of alcohol misuse
Acute intoxication Harmful use Dependence syndrome Withdrawal
31
Core features of dependence syndrome
Primacy (obtaining drug becomes most important) Continued use despite negative consequences (eg. loss of family, money) Loss of control of consumption (early morning start) Narrowing of repertoire (same drug in same setting with same people) Rapid reinstatement of dependent use after abstinence Tolerance and withdrawal
32
how does mild alcohol withdrawal present?
4-12 hours after last drink ``` Coarse tremor Sweating Tachycardia Nausea Vomiting Agitation Insomnia ``` Intense cravings Lasts 2-5 days Transient hallucinations are possible
33
Describe severe alcohol withdrawal
Peaks at 4-6 days ``` Acute confusion Amnesia Psychomotor agitation Psychosis Delirium tremens ``` Seizures: 5-15% of cases Occur 6-48hrs after last drink
34
What is delirium tremens
Medical emergency Occurs 1-7 days post drink in 5% Disoriented to time, place and person ``` Recent amnesia Hallucinations and delusions Severe psychomotor agitation Fever Autonomic disturbance and electrolyte imbalance ``` 40% mortality if left untreated
35
Management of delirium tremens (alcohol withdrawal)
Benzodiazepines for symptomatic relief (Chlordiazepoxide) Nutritional and vitamin supplementation (Thiamine and B vitamins for WErnicke's) Close monitoring Admit if: past hx of complicated withdrawal, current psychiatric symptoms, severe malnutrition, severe biochemical abnormalities
36
What is Wernicke's encephalopathy
Neuronal degeneration 2° to thiamine deficiency 1. acute confusional state 2. Ophthalmoplegia, nystagmus 3. Ataxic gait Complete triad only in 10%. Confusion in 80% Tx IV Pabrinex (B1 replacement) If left untreated, 80% progress to Korsakoff's
37
Korsakoff syndrome
Usually due to thiamine deficiency Can be chronic anterograde amnesia with some retrograde amnesia Confabulation (describe false memories) Apathy KEEP ON THIAMINE and MULTIVITs for 2 yrs!
38
Management strategies for alcohol misuse
Disulfiram (alcohol deterrent. Irreversibly inhibits ADH. Build of ADH causes flushing, headache, tachycardia and vomiting) Motivational interviewing CBT Assertiveness training (learning to say no) AA Social support
39
Biological management of opiate detox
Methadone (symptomatic tx) Lofexidine (reduces symptoms) Anti-emetics
40
Postnatal pinks
First 48hrs Temporary excitement, mild overactive with insomnia Self-resolves
41
Postnatal blues
``` 50-80% Day 3-10 Tearfulness Emotional lability Anxiety Lasts 48hrs and self-resolves ```
42
Postnatal depression
Peak onset 2-4 weeks | 50% risk of recurrence if previous severe depression or postnatal depression
43
What is used to screen for postnatal depression
Edinburgh scale!
44
When does postpartum psychosis present
50% present by day 7 Almost all by day 90 50% risk with bipolar or previous psychosis
45
Criteria for delirium
Clouding of consciousness Disturbed cognition 1 of: variable activity levels, increased reaction time, altered speecn of flow +1 of: insomnia, daytime drowsiness, nocturnal worsening of symptoms, disturbing dreams
46
Which drug can be used for rapid sedation in a patient with acute behavioral disturbance? (patient becomes aggressive/agitated or psychotic)
Lorazepam (quick onset) Anti-psychotics: olanzapine or haloperidol
47
What is acute dystonia
Reversible extrapyramidal side effects that occur due to anti-psychotics Muscle spasm occurring aywhere in the body. Can be lifethreatening if it affects laryngeal muscles!! IT is a psychiatric emergency Most common with haloperidol (in 10%) 30% Neck twisting 17% Tongue, 15% Jaw, 6% Oculogyric crisis (neck arched and eye rolled back)
48
Management of acute dystonia
Anticholinergics (Procyclidine 5-10mg)
49
When is lithium clearance reduced?
It is only renally excreted Renal impairment Sodium depletion Can be with diuretics, NSAIDs and ACEI
50
Symptoms of lithium toxicity
``` Early: Tremor Anorexia N/V/D Dehydration and lethargy ``` ``` Late: Restlessness Muscle fasciculations Myoclonic jerk Hypertonicity ``` Ataxia, dysarthria, confusion, hypotension, arrhythmias
51
Treatment of lithium toxicity
Stop lithium! Hydrate May require haemodialysis
52
What is neuroleptic Malignant syndrome
Fever Diaphoresis Rigidity Confusion and fluctuating consciousness Autonomic instability: tachycardia, salivatin and incontinence SLOW onset! Days-weeks
53
Management of neurpleptic malignant syndrome
withdraw antipsychotics!! Hydrate Consider benzos for sedation or bromocriptine
54
What is serotonin syndrome
Usually when swithcing an antidepressant or combining Or when mixing with Triptans for migraines or illicit substances ``` Various symptoms come on within a few hours: Restlessness/Agitation/confusion Hyperthermia GI upset Mydriasis Myoclonus Rigidity Tremors/convulsions Ataxia ``` Can be fatal if left untreated
55
Management of serotonin syndrome
Stop serotonergic meds Rehydrate Benzos for severe agitation Consider gastric lavage if OD