Drug Induced Liver Disease

Question 1

most frequent cause of drug induced liver injury?

Answer 1

antibiotics

Question 2

intrinsic drug induced liver injury:

Answer 2

• ersults from drug or metabolite induced direct hepatocyte damage
• predicatable at hgih doses
• occurs with short latency
• would affect the majority of the pop at high doses
• ACETAMINOPHEN

Question 3

Classic intrinsic drug induced liver injury drug?

Answer 3

acetaminophen

Question 4

idosyncratic drug induced liver injury

Answer 4

• occur in minority of susceptible people
• reactions variable and prolonged
• unexpected pharmacoogical action of drug
• less consistent relationship to dose

Question 5

most frequent reason for FDA removal of drug from market?

Answer 5

drug induced liver injury

Question 6

What is Hys law?

Answer 6

a patient will have 10% chance of dying from drug induced liver injury if:

1) serum ALT or AST> 3X ULN (upper level of normal)
2) serum total bilirubin >2 X ULN w/out findings of cholestasis
3) no other reason explains the elevation of liver enzymes

Question 7

What drug is going to cause damage to zone 1?

Answer 7

iron

Question 8

What drug causes damage to zone 2

Answer 8

cocaine

Question 9

What drug causes damage to zone 3?

Answer 9

acetaminophen