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Pharmacology > Unit 8-musculoskeletol > Flashcards

Unit 8-musculoskeletol Flashcards

1
Q

How are primary and secondary osteoarthritis different?

A

Primary/idiopathic is from physiologic changes–normal with aging. Secondary is from traumatic injuries

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2
Q

What trait sets OA apart from other disorders?

A

formation of new bone. There is a decrease in proteoglycans, decrease in cartilage, and bones remodel and can cause spurs.

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3
Q

What body areas are affected by OA?

A

knees, hips, spine, DP.

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4
Q

What are typical presenting symptoms of OA?

A

Painless crepitus, deformed joints, painful ROM

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5
Q

What is the most common finding in OA?

A

decreased ROM

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6
Q

What are herberdens nodules?

A

osteophyte in Distal interphalangeal joint (DIP)

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7
Q

What are bouchards nodules?

A

osteophyte in proximal interphalangeal joiont (PIP)

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8
Q

What is non pharmacologic treatment of OA?

A

moist heat, wt loss, exercise

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9
Q

What is first line treatment for OA?

A

APAP, 650-1000mg q 4-6hours

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10
Q

What is second line treatment of OA?

A

Nsaids

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11
Q

What is third line treatment of OA?

A

intraarticular corticosteroids

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12
Q

What is max dose of APAP? What about in ETOH?

A

4000mg/d. 1.8-2gm/d

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13
Q

What is the best PPI for NSAID induced issues?

A

omeprazole

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14
Q

What is normal dosing of capsaicin?

A

3-4x daily for 7 days.

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15
Q

What characterizes RA?

A

symmetric polyarthritic and joint changes

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16
Q

What is specific to RA?

A

formulation of pannus

17
Q

What is first line treatment for RA?

A

methotrexate if first line DMARD

18
Q

How long does methotrexate take to show improvement?

A

3-8 weeks

19
Q

What is second line treatment for RA?

A

a second DMARD after initiation of methotrexate–sulfasalazine, immoral, embroil, hummer.

20
Q

When should a DMARD be started for RA?

A

within 3 months of symptoms onset

21
Q

What is first line treatment for fibromyalgia?

A

TCAs such as nortriptyline, amitriyptiline

22
Q

What is second line treatment for fibromyalgia?

A

SSRI such as prozac

23
Q

What is third line treatment for fibromyalgia?

A

analgesic

24
Q

In whom are TCAs contraindicated? why?

A

elderly patients-can worsen glaucoma and BPH

Pharmacology (11 decks)

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