Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biology > Metabolism > Flashcards

Metabolism Flashcards

0
Q

What is a metabolic pathway?

A

a series of chemical reactions occurring within a cell.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

What is metabolism?

A

The totality of an organism’s chemical reactions. Metabolism as a whole manages the material and energy resources of the cell.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How does a metabolic pathway work?

A

begins with a specific molecule, which is then altered in a series of defined steps, resulting in a certain product.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How are enzymes apart of metabolic pathways?

A

Each step of the pathways is catalyzed by a specific enzyme.

EX. page 153 figure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Mechanisms that regulate enzymes …

A

balance metabolic supply and demand

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Catabolic pathway

A

Some metabolic pathways release energy by breaking down complex molecules to simpler compounds. AKA breakdown pathways.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is a major pathway of catabolism?

A

Cellular respiration, in which the sugar glucose and other organic fuels are broken down in the presence of oxygen to carbon dioxide and water.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Energy that was stored in the organic molecules…

A

becomes available to do the work on the cell, such as ciliary beating of membrane transport.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pathways can have more than one…

A

starting molecule and/or product.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Catabolism

A

breaking down complicated molecules into simple ones with the release of chemical energy.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Anabolism

A

building complicated molecules from simpler ones requires energy
AKA biosynthetic pathways.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

downhill and uphill avenues

A

Catabolic and anabolic pathways are the downhill and uphill avenues of the metabolic landscape. energy released from the downhill reactions of catabolic pathways can be stored and then used to drive the uphill reactions of anabolic pathways

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

enzymes

A

proteins that catalyze (speed up) chemicals reactions NOT consumed in the reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

catalyst

A

chemical agent that selectively increases the rate of a reaction without being consumed by the reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

enzyme

A

a catalytic protein. cells use proteins (enzymes to lower activation energies. Thousands of different enzymes are known, each catalyzing one or a few specific chemical reactions.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

catalysts and enzymes

A

ex. hydrolysis of sucrose by the enzyme sucrase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

bioenergetics

A

the study of how energy flows through living organisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

cells and thermodynamics

A
  • cells create ordered structures from less ordered materials
  • cells unavoidably convert organized forms of energy to heat
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

thermodynamics

A

the study of the energy transformations that occur in a collection of matter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

thermodynamics and metabolism

A

energy of

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

the laws of thermodynamics

A

1- NRG cannot be created nor destroyed, but transformed or transferred.(during ea. NRG conversion, some nrg dissipate into the environment as heat.
2-disorder (entropy) in the universe is continuously increasing (entropy is always < b/c, as more nrg is used, more nrg is converted to heat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

biological complexity and thermodynamics

A

the evolution complex organisms does not violate the principle of entropy
-entropy (disorder) may > in an organism, but the universe’s total entropy <

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Free energy, G

A
  • energy that can do work when temperature and pressure are uniform, as in a living cell
  • Measure of a system’s free energy, its tendency to change to a more stable state.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Who defined free energy?

A

Willard Gibbs in 1878.

He was a professor at yale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

DeltaG=deltaH-TdeltaS

A

The change in free energy, delta G, can be calculated for a chemical reaction by applying this equation.
delta H stands for the change in the system’s enthalpy
delta S is the change int the system’s entropy
T is the solute temperature in Kelvin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Once we know the value of delta G for a process…

A

we can use it to predict whether the process will be spontaneous (that is, whether it is energetically favourable and will occur without an input of energy)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

process of negative delta G..

A
  • are spontaneous
  • for a negative G either H must be negative or TS is positive
  • spontaneous processes decrease the system’s free energy and processes that have a positive or zero G are never spontaneous
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

This information is immensely interesting to biologists because…

A

it gives us the power to predict which kinds of change can happen without an input of energy. such spontaneous changes can be harnessed to perform work. this principle is very important in the study of metabolism, where a major goal is to determine which reactions can supply energy for cellular work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Delta G can only be negative when the process involves a loss of free energy during the change from initial state to final state…

A

because it has less free energy, the system in its final state is less likely to change and is therefore more stable than it was previously.

DeltaG= G final state-G initial state

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Equilibrium

A

A process is spontaneous and can perform work only when it is moving toward equilibrium.
most chemical rxns are reversible and proceed to a point at which the forward and backward rxns occur at the same rate.
there is no further net change (products and reactants)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

exergonic reaction (Downhill)

A

proceeds with a net release of free energy.
because the chemical mixture loses free energy(G>), G is negative for an exergonic reaction.
Exergonic reactions are those that occur spontaneously

31
Q

The magnitude of DeltaG for an exergonic reaction represents…

A

the maximum amount of work the reaction can perform.

32
Q

The greater the decrease in free energy,

A

the greater the amount of work that can be done.

33
Q

endergonic reaction (uphill)

A

absorbs free energy from its surroundings.
Because this kind of reaction essentially stores free energy in molecules (G <), G is positive. Such reactions are non spontaneous, and the magnitude of G is the quantity of energy required to drive the reaction.

34
Q

If one reaction is downhill (releasing energy in one direction),

A

the other must be uphill (using energy)

35
Q

equilibrium and metabolism

A

reaction in an isolated system eventually reach equilibrium and can then do NO work

36
Q

metabolism as a whole..

A

can never reach equilibrium

this is one of the defining features of life.

37
Q

a living cell is not in equilibrium..

A

the constant flow of materials in and out of the cell keep the metabolic pathways from ever reaching equilibrium, and the cell continues to do work throughout its life.

38
Q

A cell does three main types of work, which are powered by the hydrolysis of ATP

A

Chemical
Transport
Mechanical

39
Q

Energy coupling

A

the use of an exergonic process to drive an endergonic one

most NRG coupling in is mediated by ATP

40
Q

Chemical work

A

the pushing of endergonic reactions that would not occur spontaneously, such as the synthesis of polymers from monomers

41
Q

Transport work

A

the pumping of substances across membranes against the direction of spontaneous movement

42
Q

Mechanical work

A

such as the beating of cilia, the contraction of muscle cells, and the movement of chromosomes during cellular reproduction.

43
Q

Energy is released from ATP when..

A

the terminal phosphate bond is broken by hydrolysis

44
Q

ATP and work in cells

A

ATP is responsible for mediating most energy coupling in cells, and in most cases it acts as the immediate source of energy that powers cellular work

45
Q

reactions in a closed system

A

eventually reach equilibrium and then do not work

46
Q

a catabolic pathway in a cell releases…

A

free energy in a series of reactions

47
Q

what can serve as analogies?

A

closed and open hydroelectric systems

48
Q

living organisms have the ability to couple exergonic and endergonic reactions:

A

NRG released by exergonic reactions is captured and used to make ATP from ADP and Pi
ATP can be broken back down to ADP and Pi, releasing energy to power the cell’s endergonic reactions

49
Q

ATP

A
  • Is the cells energy shuttle

- provides energy for cellular functions

50
Q

Releasing the third phosphate from ATP to make ADP…

A

generates energy (exergonic)

51
Q

linking the phosphates together requires NRG:

A

so making ATP from ADP and a thrid phosphate requires NRG (endergonic)

52
Q

Catabolic pathways drive the…

A

regeneration of ATP from ADP and phosphate

53
Q

ATP drives endergonic reactions by phosphorylation,

A

transferring a phosphate group to some other molecule, such as a reactant
The recipient molecule is now phosphorylated

54
Q

ATP is an excellent energy donor

A

because electrostatic repulsion, the covalent bonds between phosphates are unstable

55
Q

regeneration of ATP from ADP and Pi

A

catabolic reactions in the cell->energy to phosphorylate ADP

Pool of ATP turns over at a very fast rate (10 million/sec in a muscle cell)

56
Q

Enzymes speed up reactions

A

DO NOT affect the change in free energy; they speed reactions that would occur eventually (exergonic)

57
Q

Free energy of activation, or activation energy (EA)

A

the initial energy needed to start a chemical reaction

often supplied in the form of heat from the surroundings

58
Q

activation energy

A
  • is the initial amount of energy need to start a chemical reaction
  • needed to bring the reactants close together and weaken existing bonds to initiate a chemical reaction
  • often supplied in the form of heat from the surroundings in a system
59
Q

What reactants require an input of energy to get started?

A

both endergonic and exergonic ( this energy is called activation energy)

60
Q

What lowers the EA barrier of reactions?

A

Enzymes

61
Q

what is activation energy?

A

the amount of energy needed to push the reactants to the top of an energy barrier, or uphill, so that the downhill part of the reaction can begin

62
Q

What is activation energy normally supplied by?

A

supplied by heat in the form of thermal energy that the reactant molecules absorb from the surroundings.

63
Q

what does the absorption of thermal energy do?

A

accelerates the reactant molecules, so they collide more often and more forcefully. It also agitates the atoms within the molecules, making the breakage of bonds more likely.

64
Q

what happens when the molecules have absorbed enough energy for the bonds to break?

A

the reactants are in an unstable condition known as the transition state

65
Q

How do enzymes increase the speed of reactions?

A

an enzyme catalyzes a reaction by lowering the EA barrier, enabling the reactant molecules to absorb enough energy to reach the transition state even at moderate temperatures.

66
Q

What can’t an enzyme do?

A

enzymes cannot change the delta G for a reactions; it cannot make an endergonic reaction exergonic.

67
Q

What can enzymes only do?

A

they can only fasten reactions that would eventually occur anyway,but this function makes it possible for the cell to have a dynamic metabolism, routing chemicals smoothly through the cell’s metabolic pathways.

68
Q

Because enzymes are very specific for the reactions they catalyze,

A

they determine which chemical processes will be going on in the cell at any particular time.

69
Q

substrate

A

the reactant an enzyme acts on

70
Q

enzyme-substrate complex

A

formed when the enzyme binds to its substrate of substrates when there is more than one reactant

71
Q

what happens when the enzyme and substate are joined?

A

the catalytic action of the enzyme converts the substate to the product (or products) of the reaction.

72
Q

Enzyme changes shape such that its active site…

A

enfolds the substrates.

brings chemicals groups of the active site into positions that enhance their ability to catalyze the reactions.

73
Q

factors that affect enzyme activity.

A

general environment factors-temperature and pH

chemicals that specifically influence the enzyme

74
Q

Can enzymes work in forward and reverse directions?

A

some can

75
Q

there are different forms of some enzymes,

A

that assist different reactions.

  • cytosolic version of enzyme
  • mitochondrial version of enzyme

Biology (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions