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Pharm 1 > exam 2 > Flashcards

exam 2 Flashcards

0
Q

cephalosporins

A

ICWS

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1
Q

penicillins

A

ICWS

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2
Q

monobactams

A

ICWS

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3
Q

carapenems

A

ICWS

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4
Q

vancomycin

A

ICWS

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5
Q

fosfomycin

A

ICWS

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6
Q

bacitracin

A

ICWS

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7
Q

aminoglycosides

A

30s inhibitor

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8
Q

tetracycline

A

30S inhibitor

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9
Q

glycylcyclines

A

30S inhibitor

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10
Q

macrolides

A

50S inhibitor

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11
Q

ketolides

A

50S inhibitor

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12
Q

streptogramin

A

50S inhibitor

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13
Q

oxazolidinones

A

50S synthesis

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14
Q

“broad spectrum”

A

50s inhibitors

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15
Q

fluoroquinolones

A

DNA gyrase

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16
Q

metronidazole

A

DNA fragmentation

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17
Q

nitrofurantoin and methenamine

A

DNA damage

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18
Q

sulfonamide

A

folic acid metabolism

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19
Q

daptomycin

A

binds to membrane and depolarizes it

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20
Q

mupirocin

A

binds to tRNA synthase

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21
Q

polypeptide antibiotics

A

binds to G- cell membrane phospholipids

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22
Q

isoniazid

A

inhibits synthesis of mycolic acid

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23
Q

rifampin

A

inhibits DNA dependent RNA polymerase

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24
Q

ethambutol

A

inhibits arabinosyl transferase

25
Q

pyrazinamide

A

unknown mechanism

26
Q

streptomycin

A

30S inhibitor

27
Q

Dapsone

A

interferes w/ folic acid metabolism

28
Q

amphotericin B

A

cell wall inhibitor

29
Q

Azoles

A

cell wall inhibitor

30
Q

echinocandins

A

cell wall inhibitors

31
Q

Flucytosine

A

metabolic antagonism of fungal DNA and RNA

32
Q

griseofulvin

A

binds microtubules

33
Q

terbinafine

A

interferes w/ sterol biosynthesis

34
Q

oral penicillinase resistant penicillins

A

Dicloxacillin

Oxacillin

35
Q

oral 1st gen cephalosporin

A

cephalexin

36
Q

oral 2nd gen cephalosporins

A

ceflacor

cefprozil

37
Q

oral 3rd gen cephalosporins

A

cefixime

38
Q

drug w/ MAOI side effects

A

linezolid

39
Q

monobactam spectrum

A

aerobic G- rods

40
Q

carapenem spectrum

A

G+, G-, aerobes, anaerobes

41
Q

aminoglycoside spectrum

A

aerobic G- enteric rods

42
Q

tetracycline spectrum

A

G+, G-, anaerobes, aerobes, atypicals

43
Q

macrolide spectrum

A

G+

44
Q

ketolide spectrum

A

broad

45
Q

fluoroquinolone spectrum

A

aerobic G- rods w/ G+ coverage as well

46
Q

polypeptide antibiotic spectrum

A

G-

47
Q

mupirocin spectrum

A

G+, some G-

48
Q

cephalosporin toxicity risk

A

nephrotoxicity

49
Q

carapenem risk

A

imipenem and cilstatin- seizure risk

50
Q

vancomycin toxicities

A

ototoxicity

nephrotoxicity

51
Q

bacitracin toxicity

A

parenteral- nephrotoxicity

52
Q

fluoroquinolone toxicities

A

increased QT interval

cartilage issues

53
Q

sulfonamide toxicities

A

SJS

kernicterus- not for infants

54
Q

polypeptide antibiotic toxicity

A

nephrotoxic, use only topically

55
Q

cephalosporins w/ CNS penetration

A

Ceftriaxone

Cefotaxamine sodium

56
Q

tx for osteomyelitis

A

clindamycin

57
Q

only drug w/ 100% CNS penetration

A

Chloramphenicol

58
Q

the only bacteriocidal protein synthesis inhibitor

A

aminoglycoside

59
Q

which drugs interfere with the P450 system?

A

erythromycin
rifampin
ketoconazole

60
Q

drugs that elevate liver enzymes

A

caspofungin

flucytosine

61
Q

antifungals w/ CSF penetration

A

fluconazole

flucytosine

Pharm 1 (3 decks)

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