AA Metabolism Khan Flashcards
1
Q
- T or F: AA’s maintain blood pH levels
A
- True
2
Q
- What are proteins that undergo extensive synthesis and degradation in reticulocytes?
A
- Heme Products
3
Q
- T or F: heme has a long half life
A
- F
4
Q
- T or F: collagen has a long half life
A
- True
5
Q
- What are some factors affecting the rates of protein degradation?
A
- Glucocorticoids (increase degradation), thyroid hormones (protein turnover), insulin
(protein synthesis), lysosomes (proteolysis), denaturation
6
Q
- What are 4 AA’s degraded via the ubiquitin protesome pathway?
A
- P,E,S,T
7
Q
- Presence of what AA’s make protein unstable at N terminus?
A
- FLDKR
8
Q
- What are the essential AA’s?
A
- Arg, His, Ile, Leu, Lys, Met, Phe, Thr, Trp, Val (MILK RH FTW V)
9
Q
- Lack of a single AA can give rise to wasting disease called?
A
- Kwashiorkor (causes edema due to increased osmotic pressure in interstitium)
10
Q
- What are 3 ways AA’s are absorbed?
A
- Sodium cotransport, facilitated transport, g‐glutamyl cycle
11
Q
- What is re‐converted to GSH in the g‐glutamyl cycle?
A
- Oxyproline
12
Q
- What is hartnups disease?
A
- Inability to absorb neutral/aromatic AA’s
13
Q
- What are symptoms of hartnups disease?
A
- Dermatitis, diarrhea, dementia
14
Q
- Decrease in cysteine uptake can cause?
A
- Cystinuria via oxidation to cystine in urine
15
Q
- How does penicillamine alleviate cystinuria?
A
- Reacts with one Cys to form cys‐penicillamine
