2D- Pedigree Analysis Flashcards Preview

Medical Genetics > 2D- Pedigree Analysis > Flashcards

Flashcards in 2D- Pedigree Analysis Deck (7)
Loading flashcards...
1

Describe the meaning of the symbols used in pedigree charts for male, female, affected, carrier and deceased individuals 

2

Describe the arrangement of lines indicating mating, parentage and offspring 

3

Be able to use the specific symbols for consanguinity, identical and fraternal twins 

4

Be able to construct pedigrees showing autosomal dominant  inheritance patterns 

5

Be able to construct pedigrees showing autosomal recessive inheritance patterns 

6

Distinguish the circumstances in which carriers will or will not be indicated on a pedigree that you must interpret. 

7

Determine the Coefficient of Relationship between two first cousins

(1/2)4= 1/16 for each cousin
 
If individuals A and E shared only one grandparent, the coefficient would be 1/16. But since they share a common grandfather and grandmother; two paths through which the disease gene could have traveled.

Therefore we can add up these two paths/probabilities (1st from F and 2nd from C)to get the overall probability that A and E share a disease gene: 1/16 + 1/16 = 1/8