3-31-13

Question 1

H. Influenza B causes what in kids?

Answer 1

Common cause of Epiglotitis and Otidis media in kids.

Question 2

H influenza B vaccine tips?

Answer 2

Vaccination HiB is conjugated: Toxoid + capsular protein.

Question 3

What is the purpose of conjugating vaccine such as HiB

Answer 3

To stimulate Th2 cell to make cytokines to stimulate B cells to isotype switch.

Question 4

Attenuated vaccines?

Answer 4

Live vaccines that have been weakened.

Ex: MMR

Question 5

Killed- whole cell vaccines?

Answer 5

Killed bacteria vaccines that the organism have been inactivated.
Ex: Samonella and bordatella.

Question 6

Toxoid vaccines?

Answer 6

Made from inactivated bacterial toxins.

Ex: Diphteria and tetanus.

Question 7

Electrolytes/hormone disturbances in 21 alpha hydroxylase deficiency?

Answer 7

Hyponatremia, hypochloremia.
Decreased aldosterone
Hyperkalemia, elevated BUN.
Elevated 17-hydroxyprogesterone levels.

Question 8

What CREST stands for?

Name antibody found to elevated?

Answer 8

Calcinosis. Raynaud phenomenon. Esophageal dysfunction. Sclerodactyly. Telengiectesias.
Anti-Centromere antibody.

Question 9

Anti-RNP is a good marker for?

Answer 9

Mixed connective tissue disease.

Question 10

Anti-SSA, Anti-SSB, Anti-RAP. Rho-la. good marker for?

Answer 10

Sjogran disease.

Question 11

Anti-dsDNA and Anti-SM marker for?

Answer 11

SLE

Question 12

Anti-SCL-70 good marker for

Answer 12

Scleroderma.

Question 13

C. diphtheria toxin works by?

Answer 13

Inactivating Translation Elogantion factor 2 (eEF-2) via ADP-riboxylation.
This inhibits cell protein synthesis.

Question 14

Fluoxetine drug use for?

Answer 14

MC used with Major Depression

Question 15

Remember that MCC of Pelvic Inflammatory Disease is?

Answer 15

Chlamydia and N. Gonnorrhea.

Question 16

ELISA

Answer 16

good test when trying to find out if a person has antibody to a particular thing.

Question 17

Northem used to determine what?

Answer 17

RNA levels in a cell.

Question 18

Southern blot used to determine what?

Answer 18

Used to study genomic DNA.

Question 19

PCR reactions good for?

Answer 19

Ampliflying small pieces of DNA for DNA mapping or sequencing.

Question 20

BRACA-1 gene associated with what?

Answer 20

Breast and ovarian cancers. This tumor suppressor gene is located in the chromosome 17q

Question 21

Berry aneurysm is associated with what conditions?

Answer 21

Marfan. Ehlers-danlos. APKD. HTN. Smoking.

Question 22

Polymyalgia rheumatic associated with?

Answer 22

Temporal arteritis => headaches and jaw claudication.

Question 23

Salicylate intoxication look for first?

Answer 23

Tinnitus as the first sign of intoxication.

Acidosis and Hyperventilation occurs after very high levels of intoxication.

Question 24

mental retardation associated with chromosomal breakage think?

Answer 24

Fragile X syndrome.
Culture lynphocyte with methotrexate and look for specific breakpoints.
Trinucleotide repeates are the site of breakage and gets worse in each next generation.

Question 25

Acethamenophem OD give?

Answer 25

Acetylcysteine=> works by repleneshing glutathione levels = thus protecting the liver from damage.

Question 26

what is the cardiac manifestation involved with SLE?

Answer 26

Libman-sacks endocarditis can occur with SLE.

Question 27

Pts with Type DM rely on what mechanism to increase blood sugar?

Answer 27

It cannot use Glucagon so it acutly is used epinerphrine and chronically can use cortisol

Question 28

Migratory thrombopheblitis

Answer 28

Formation and dissolution of clots secondary to tumors that secrete platelet aggragating factors. Common seen with pancreatic CA.

Question 29

Generalized transduction

Answer 29

requires the presence of a virus to transfer the DNA from one bacterium to another.

Question 30

Conjugation

Answer 30

genetic exchange involving cell to cell transfer of DNA. Bacteria sex!

Question 31

Metaformin vs Glipizide to tx diabetes

Answer 31

Choose Glipizide if the pt has mild to moderate renal issues. Glipizide undergoes hepatic clearance.

Question 32

Otitis media with bone invasion think?

Answer 32

Pseudomonas aeruginosa.

Question 33

Pseudomonas aeruginosa.

Answer 33

GNR. Ox +. Produce blue-green pigments.

Question 34

PTH hormone electrolytes?

Answer 34

Increase serum calcium. Increase cAMP present in the Urine. Decrease phosphate.

Question 35

McArdle disease: chronic exercise intolerance with myalgia, fatigue, painful cramps and

Answer 35

Due to Glycogen phosphorylase deficiency.