3 A: Anatomy of Liver Flashcards Preview

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Flashcards in 3 A: Anatomy of Liver Deck (30):
1

The liver consists of what lobes?

Right, left, quadrate and caudate lobes

***Which are composed of functional units called LOBULES

2

What do lobules consist of ?

-Rows upon rows of hepatocytes

3

How does blood flow past hepatocytes?

Via sinusoids from branches of the hepatic portal vein to the central vein of each lobule

4

What do Canaliculi do?
What organ stores and makes bile?

-Carry bile

-Liver: makes
-Gall bladder: stores

5

What does a lobule consist of (micro anatomy)

Central vein, hepatocytes, sinusoid, portal triad, bile duct, hepatic artery, and hepatic portal vein

**Hexagon shaped

6

How does piggy liver differ from human liver lobules?

Microscopically the CT between the lobules is thick therefore when consuming it, it takes better.

7

What is a portal triad (tetrad)?

1) portal vein
2) hepatic artery
3) bile duct
*4) lymphatic vessel

8

What are inside the sinusoids?

Hepatic macrophages called KUPFFER CELLS

9

What are Kupffer cells?

Remove debris such as bacteria and worn-out RBCs

10

What are bile canaliculi?

They run parallel to the sinusoids and drain bile produced by the hepatocytes

11

Within each lobule, what is included?

Hepatocytes are arranged into HEPATIC CORDS separated by adjacent sinusoids.

12

What happens to the arterial blood and venous blood?

They mix in the lobule

13

What is the arterial blood flow through the liver?

1) Begins by delivering oxygenated blood from hepatic artery
2) Liver sinusoids
3) central vein
4) hepatic vein
5) inferior vena cava
6) R. atrium of heart

14

What is the PORTAL blood flow through the liver?

1) Begins by delivering "Nutrient-rich", deoxygenated blood from hepatic portal vein
2) Liver sinusoids
3) central vein
4) hepatic vein
5) inferior vena cava
6) R. atrium of heart

15

What is the portal vein formed by?

1) Splenic vein (spleen)
2) inferior mesenteric vein (left colon, rectum)
3) superior mesenteric vein (right colon, s. intestine, pancreas)

16

Anything going to your intestine goes thru what?

the portal system

17

What are the sinusoids lined by?

Fenestrated endothelium (easy for exchange)

18

What is unique about the endothelium in the sinusoids?

NO underlying basement membrane

19

What do the fenestrations allow?

They permit blood plasma to wash freely over the exposed surfaces of the hepatocytes in the space of DISSE.

20

What is the space of DISSE?

The perisinusoidal space (in between hepatocytes and sinusoids)

21

Which direction does the sinusoidal blood flow?

Always TOWARDS the central vein

22

Since substances in the plasma move freely into the spaces of Disse what must the liver do?

MUST have an extremely high lymph flow to PREVENT accumulation of interstitial fluid

23

What happens if the pressure rises int he portal veins & sinusoids ?

Excessive amount sod fluid begin to transude into the lump and to leak through the outer surface if the liver capsule directly into the abdominal cavity producing ASCITES

24

What is ASCITES?

-Greek for "bag or sac"
-Describes the condition of pathologic fluid accumulation whine the abdominal cavity.

25

Do men and woman have intraperitoneal fluid? How much?

-Health men have little or none
-Women can have 20 ml depending on the phase of the menstrual cycle

26

Why is the liver a prime site for the spread of cancerous cells (metastasis) from elsewhere in the body, especially from the GI tract, breast and lung ?

Because of its portal blood supply and extensive lymphatic circulation

27

What is the First Pass Effect?

Most drugs absorbed form the GI tract enter the portal circulation and encounter the liver before they are distributed into the general circulation

28

What happens to oral meds taken my mouth?

-They are absorbed out of the intestines into the portal system and will be first seen in the liver before circulated. Liver will degrade/metabolize medications

29

What is the effect of a medication with 100% pass effect ?

It will be useless because all of it will get broken down by the liver
(The minute it is absorbed all of it got broken down and none went to circulation; try different method of administration of drug)

30

Trace the hepatobiliary plumbing ?

R/L hepatic ducts-->common hepatic duct-->common bile duct