3 L6 Depressants

Question 1

What does MDMA release

Answer 1

Serotonin

Question 2

Does MDMA cause physical dependence

Answer 2

No- there is limited evidence that t does

Question 3

Seratonin releasing agents tolerance

Answer 3

They exhibit rapid tolerance- 5HTR are rapidly desensitised and down regulated

Question 4

MDMA dependence

Answer 4

Heavy use of MDMA is associated with short term down regulation of SERT- More use, however, was not associated with more SERT downregulation - Abstinence from MDMA abstinence correlated with increasing SERT levels

Question 5

What are Hallucinogens/Physcadelics agonists of and what kind of receptor is it

Answer 5

5HTR- Gq coupled GPCR

Question 6

Hallucinogens/Physcadelics tolerance

Answer 6

Rapidly develops- 5HTR down regulate- lowers desire/ability to redose

Question 7

Hallucinogens/Physcadelics physical dependence

Answer 7

Physical dependence is uncommon with psychedelic drugs

Question 8

Psychedelic dependence with increasing use

Answer 8

Cases of dependence can also increase

Question 9

What appears to drive tolerance of 5HT receptors

Answer 9

Internalisation of receptors into the cell- More agonst required to reach same level of intracellular signalling molecules

Question 10

5HTR and dopamine release type

Answer 10

They do not cause a phasic release of dompanine into nucleus accumbens- Low physical dependence risk, No downregulation of dopamine receptors

Question 11

Describe disinhibition of depressants

Answer 11

Depressants can still stimulate certion regions of the brain- High doses cause general inhibition (anaesthesia), Very high doses cause trauma and death

Question 12

Alcohol relative dose size

Answer 12

Dose of alcohol reached in body is 100 times greater than most pharmaceutical drugs- Low potency

Question 13

Alcohol mechanism

Answer 13

Alcohol is a PAM for GABA A receptors

Question 14

Alcohol affect on neuron firing in the