3 MHC And TCR Flashcards

1
Q

(TP) identify which of the following cells lack MHC-1

A) neutrophils

B) lymphocytes

C) Red Blood Cells

A

C) red blood cells!!

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2
Q

(LO) MHC Class I is ________ and CD_

MHC Class II are ______ and ____ and CD_

Only cells that recognize T-cells are MHC____

A

…all nucleated cells; CD8

B-Cells and APCs; CD4

MHC II!!!!

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3
Q
(LO) Recognize the MHC class I & class II domains responsible for binding
antigen, and the types of antigens presented.
A

..

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4
Q
(LO) Recognize the structure of the T-cell receptor (TCR), and explain the
function of the CD3 complex.
A

..CD3 required for development and function

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5
Q

(LO) Know which type of lymphocytes express CD4, CD8, and CD28

A

T-cells!!

CD4/MHC-II

CD8/MHC-I

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6
Q

(LO) Explain the function of TCR accessory molecules

A

..important for signal transduction after activation and stabilization

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7
Q

(LO) Differentiate the roles of TH1 and TH2 lymphocyte

A

TH1 promotes CELL mediated responses. Drive Tc cells and NK cells. Release IFNy and TNFB.

TH2 cells promote ANTIBODY-mediated responses. Drives B-cell activation. Release IL-4 and 10

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8
Q

What class of MHC is recognized by Cd-4?

Cd-8?

A

MHC II

MHC I

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9
Q

Do red blood cells have any MHC I or II? What about the placenta?

A

NOOOOOO

No again, not this time placenta

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10
Q

Tc cells ______ recognize peptides bound to MHC class I.

Tc cells ____ recognize peptides bound to MHC class II.

A

CD-8

CD-4

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11
Q

MHC Class I has three major loci ________

MHC Class II has three major loci ___________

A

A, B, C

DP, DQ, DR

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12
Q

Why is MHC Class I omnipresent?

A

Because every cell can become cancerous, get infected by viruses, etc. we need a way to clear the body!!

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13
Q

Are endogenous antigens phogocytized?

What presents them?

What are they presented to?

A

NOT phagocytized

Presented by: MHC I

Presented to: Tc lymphocytes: CD-8

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14
Q

Are exogenous antigens phogocytized?

What presents them?

What are they presented to?

A

YES! Phogocytized material

Presented by MHC II

Presented by Th lymphocytes: CD-4

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15
Q

If you see a picture of a MHC class structure, if you see CD-8 coming down with one long streak.. it’s going to be MHC Class _____

A

MHC Class I structure

A3 is the docking site for CD8

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16
Q

If you see a picture of a MHC class structure, if you see CD-4 coming down with two long streaks.. it’s going to be MHC Class _____ .

What’s the docking station for CD4?

A

MHC CLASS II

A1 and B1 polymorphic and bind to Ag and present to Th cell

B2 is docking station for CD4

17
Q

What’s the portion of an antigen that is bound by an antibody or T-cell receptor? Antigens are covered in these

A

Epitope!!

18
Q

What’s a substance that can react with an antibody, but CANNOT induce the formation of antibodies unless bound to a carrier protein or other molecule?

A

Hapten

19
Q

What is the TCR made up of?

The variable region (TOP) binds antigen presented by _______ (all nucleated cells) or by _______ (APCs)

Closely associated with ______ complex and accessory molecules

A

One A and B chain

MHC-I

MHC-II

CD3

20
Q

What is required for TCR development and function?

A

CD3

21
Q

Which cells promote CELL-mediated responses? Release?

Which cells promote ANTIBODY-mediated responses? Release?

A

TH1; IFNy TNFb

TH2; IL-4, IL-10