3. Principles of Neoplasia Flashcards Preview

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Flashcards in 3. Principles of Neoplasia Deck (41):
1

Cancer(s) caused by aflatoxins (Aspergillus derived rice/grain contaminant).

Hepatocellular Carcinoma

2

Cancer(s) caused by alkylating agents

Leukemia/lymphoma

3

Cancer(s) caused by alcohol.

Squamous cell carcinoma of oropharynx and upper esophagus
Hepatocellular carcinoma
Pancreatic carcinoma

4

Cancer(s) caused by arsenic (poison and cigarette smoke)

Squamous cell carcinoma of skin
Lung cancer
Angiosarcoma of liver

5

Cancer(s) caused by asbestos.

Lung carcinoma (more common)
Mesothelioma

6

Cancer(s) caused by cigarette smoke (polycyclic hydrocarbons).

Carcinoma of:
Oropharynx
Esophagus
Lung
Kidney
Bladder
Pancreas

7

Cancer(s) caused by Nitrosamines

Stomach carcinoma (intestinal type)

8

Cancer(s) caused by Naphthylamine (cigarette smoke)

urothelial carcinoma of bladder

9

Cancer(s) caused by Vinyl chloride (used to make PVC).

angiosarcoma of liver

10

Cancer(s) caused by Nickel, Chromium, Beryllium, or silica.

Lung carcinoma

11

Cancer(s) caused by EBV.

Nasopharyngeal carcinoma
Burkitt lymphoma
CNS lymphoma in AIDS

12

Cancer(s) caused by HHV-8.

Kaposi sarcoma

13

Cancer(s) caused by HBV and/or HCV.

Hepatocellular carcinoma

14

Cancer(s) caused by HTLV-1.

Adult T-cell leukemia/lymphoma

15

Cancer(s) caused by HPV (16, 18, 31, 33).

Squamous cell carcinoma of vulva, vagina, anus and cervis.
Adenocarcinoma of cervix

16

Cancer(s) caused by ionzing (nuclear) rediation.

AML
CML
Papillary carcinoma of the thyroid

17

Cancer(s) caused by non-ionizing radiation (UVB).

BCC
Squamous cell carcinoma of skin
Melanoma

18

What tumor is due to overexpression of PDGFB (autocrine loop)?

astrocytoma

19

What tumor is due to amplification of ERBB2 (Her2/Neu)?

Some breast carcinomas

20

Whats tumor are due to point mutations in RET?

MEN2A and MEN2B and sporadic medullary carcinoma of the thyroid

21

What tumor is due to point mutations in KIT?

GI stromal tumor

22

What tumors are due to t(9;22) of ABL iwth BCR?

CML
some times of adult ALL

23

What tumor is due to t(8;14) of c-MYC under IgH promoter?

Burkitt lymphoma

24

What tumor is due to amplification of n-MYC?

neuroblastoma

25

What tumor is due to amplification of L-MYC?

small cell lung carcinoma

26

What tumor is due to t(11;14) placing Cyclin D under IgH promoter?

Mantle cell lymphoma

27

What tumor is due to amplificaiton of CDK4?

melanoma

28

What immunostain shows epithelium (carcinoma)?

keratin

29

What immunostain shows mesenchyme (sarcoma)?

vimentin

30

What immunostain shows muscle?

desmin

31

What immunostain shows neuroglia?

GFAP

32

What immunostain shows neurons?

neurofilament

33

What immunostain shows prostatic epithelium?

PSA

34

What immunostain shows breast epithelium?

ER

35

What immunostain shows thyroid follicular cells?

thyroglobulin

36

What immunostain shows neuroendocrine cells (ex. SCC of lung or carcinoma)?

chromogranin

37

What immunostain shows Melanoma, Schwannoma, and Langerhans cell histiocytosis?

S-100

38

How is clonality of B lymphocytes determined?

Ig light chain phenotype

39

What is the normal kappa to lambda light chain ratio?

3:1

40

How many divisions does it take before the earliest clinical symptoms of a cancer arise?

around 30

41

What 2 findings are seen in familial retinoblastoma?

bilateral retinoblastoma
osteosarcoma