Pulm CC II - Taneja Flashcards

1
Q

What is the differential diagnosis for cough?

Yes, I’m serious.

A

Bronchitis, URI, pneumonia, sinusitis, asthma, ACE-I use, CHF.

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2
Q

What is the differential diagnosis for hemoptysis?

A

Bronchiectasis, Bronchitis, Cancer, Vasculitis, Tuberculosis, Trauma, presumably many others…

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3
Q

Name two clinical signs that provoke a high suspicion for neoplasm.

A

Weight loss

Palpable mass

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4
Q

Which lung neoplasms are generally seen in smokers?

Where are they distributed?

A

Squamous & Small-cell carcinomas.

Both are central.

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5
Q

A lung biopsy reveals submucosal expansion of what appears to be lymphocytes. However, they are CD3/TCR/BCR negative. What is this expansion?

A

Small cell carcinoma.

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6
Q

Why is the workup for a small cell carcinoma to MRI the head, CT the body, and conduct a bone scan?

Describe its staging.

A

To look for metastases, which have probably already occurred before the visit.

Small cell CA is staged either “limited” or “extensive”.

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7
Q

What is the differential diagnosis for dyspnea?

A

Cardiac insufficiency, musculoskeletal decompensation or deconditioning, renal/hepatic disorders (eg protein loss), psychiatric/anxiety, and many many pulmonary causes.

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8
Q

What is the differential diagnosis for Erythema Nodosum?

A

Drugs, autoimmune diseases (IBD, Sarcoidosis), pregnancy, infections, various cancers.

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9
Q

What is the significant finding on this CXR?

What disease is this?

A

Bilateral hilar lymphadenopathy.

Sarcoidosis (stage I)

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10
Q

What are some alternatives to bronchoscopy and open-lung biopsy for specimen collection?

A

If superficial enough, fine-needle aspirations can be done non-invasively.

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11
Q

What is the differential for non-caseating granulomas?

Necrotizing (caseating) granulomas?

A

Non-caseating: Wegener’s, Crohn’s, HSR, Sarcoidosis.

Caseating: TB & Fungal infections (Histo/blasto)

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12
Q

A patient presents with fever, tachycardia, tachypnea, confusion, and BP 120/80.

Is this patient in SIRS, Sepsis, or Septic Shock?

A

Sepsis; SIRS requires fever and tachypnea/tachycardia. CNS involvement progresses the diagnosis to sepsis, but there is not sufficient hypotension to be considered septic shock.

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13
Q

What is the significance of bronchial breath sounds where there should be vesicular breath sounds?

A

Indicates consolidation or cavitation.

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14
Q

What is the most common cause of pneumonia?

A

Streptococcus Pneumoniae.

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15
Q

Distinguish between the gross appearances of bronchopneumonia and lobar pneumonia.

A

Bronchopneumonia has multiple foci which may coalesce later in disease.

Lobar pneumonia uniformly affects a large section of lung, generally an entire lobe.

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16
Q

What are the 4 stages of progression of lobar pneumonia?

What is seen in each of them?

A

Congestion (septal engorgement), Red hepatization (more neutrophils), grey hepatization (more fibrin, inflammatory debris), resolution.

17
Q

Diagnose:

A

ARDS

18
Q

What are the clinical requirements for ARDS diagnosis?

What can cause it?

A

Acute onset, severe hypoxemia, (fluid overload?), bilateral diffuse interstitial infiltrates.

Many causes: Infection, HSR, emboli…

19
Q

Describe the progression of ARDS.

What is seen in histology?

A

Initial stage is Exudative; Later stage is Proliferative.

Hyaline membranes, RBC infiltration.

20
Q

How many patients survive ARDS?

How is their long-term prognosis?

A

Probably slightly more than half, nowadays.

Many experience chronic symptoms.