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MID Exam 3 > Exam 3 - Picorna-Caliciviruses > Flashcards

Exam 3 - Picorna-Caliciviruses Flashcards

1
Q

Picornaviruses

General profile

A

ss + RNA

genome can be mRNA

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2
Q

Picornaviruses

3 relevant families

A

Entero- (polio/non-polio)
Hepato- (Hep A)
Rhino-

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3
Q

Picornaviruses
Entero
pathophys

A
  • depends on host cell receptors
  • replication > lysis
  • viremia
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4
Q

Picornaviruses
Entero
epi/transmiss

A
  • fecal-oral
  • URI/inhalation
  • summer/early fall
  • infants/young
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5
Q

Picornaviruses
Nonpolio entero
3 categories

A

coxsackie-
ECHO-
entero-

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6
Q

Picornaviruses
Nonpolio entero
general sx

A
  • mostly asx

- fever, lethargy, anorexia, vomit, diarrhea

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7
Q

Picornaviruses
Nonpolio entero
major viremia sx

A

-meningitis, enchephalitis
-myocarditis
pleurodynia, myositis
-perinatal infxn
-viral exanthema (herpangina - cox A)
-viral exanthama (handfootmouth - cox A16)

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8
Q

Picornaviruses
Nonpolio entero
Herpangina infxn

A

-Cox A
-fever, sore throat, vesicular enanthem
on soft palate, tonsils; ulcerates
-summer, children

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9
Q

Picornaviruses
Nonpolio entero
Hand-Foot-Mouth

A
  • coxsackie A16
  • children 3-10
  • vesicular oral enanthem
  • papulovesicular exanthem hands, feet
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10
Q

Picornaviruses
Nonpolio entero
Dx

A
  • cell culture

- PCR

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11
Q

Picornaviruses
Nonpolio entero
Tx

A

self-limited

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12
Q

Picornaviruses
polio entero
epi/transmiss

A
  • human res
  • summer/fall
  • vacc 1955
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13
Q

Picornaviruses
polio entero
sx

A
  • mostly asymptomatic
  • prim: fever, myalgia
  • aseptic meningitis
  • asymmetric flaccid paralysis (ant horn cell)
  • cranial nerve paralysis (medulla/stem)
  • resp paralysis > death
  • if you live, myalgia sequelae
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14
Q

Caliciviruses

general profile

A

-ss + RNA

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15
Q

Caliciviruses

relevant spp

A

Norovirus

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16
Q

Caliciviruses
Norovirus
epi/transmiss

A
  • # 1 food-borne enteroinfxn
  • fecal-oral, surface, inhaled
  • high mutation rate
17
Q

Caliciviruses
Norovirus
Norwalk

A
  • fever, anorexia, vomiting, diarrhea

- cruise ships!

18
Q

Caliciviruses
Norovirus
Dx

A

Stool PCR

MID Exam 3 (13 decks)

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