111814 viruses

Question 1

influenza viruses A, B can cause what diseases

Answer 1

rhinitis
pharengitis
croup
bronchitis
bronchiolitis
pneumonia

Question 2

rhinoviruses can cause what kind of diseases

Answer 2

rhinitis

pharengitis

Question 3

respiratory viruses

Answer 3

influenza 
rhinovirus
enteroviruses
coronavirus
parainfluenza virus
RSV
metapneumonovirus
adenovirus

Question 4

which viruses can have viremia?

Answer 4

measles
adenovirus
enteroviruses

Question 5

enteroviruses

Answer 5

measles
EBV
HSV
CMV

Question 6

pathogenesis of influenza

Answer 6

virus replication-destruction of respiratory epithelium
cell damage also due to virus activated cytotoxic T cells

decreased clearance
risk of bacterial infec

Question 7

systemic symptoms of influenza A and B are caused by

Answer 7

interferon and cytokine response to virus

Question 8

antiviral therapy

Answer 8

zanamivir, oseltamivir

they’re neuraminidase inhibitors

Question 9

what viruses cause summer colds and “flu”

Answer 9

enteroviruses

get common cold symptoms
fever, headache, fatigue

Question 10

what do coronaviruses cause?

Answer 10

common colds (second most prevalent cause)

SARS
MERS (acute severe pneumonia, renal failure)

Question 11

when do parainfluenza virus infec usually occur

Answer 11

fall, winter

Question 12

RSV pathogenesis

Answer 12

blockage of narrow airways of INFANTS (virus induced CPE includes syncytia-multinucleated cells. induction of inflam cytokines)

infects virtually everyone by age 2
natural infec don’t prevent RE-infection

Question 13

clinical consequences of RSV infec

Answer 13

bronchiolitis, pneumonia, or both (in children younger than 1 yr)

febrile rhinitis and pharyngitis (children)

common cold (older children, adults)

Question 14

what can premature infants get for prevention of RSV infec?

Answer 14

passive immunization with anti-RSV Ig and humanized monoclonal antibodies

Question 15

metapneumovirus

Answer 15

clinical spec of disease similar to RSV but in general milder

by 5 yrs of age, almost all children have had it

Question 16

Hendra and Nipah viruses

Answer 16

paramyxoviruses
emerging, high mortality rates
made the jump from bats to people with pigs

Question 17

adenovirus

Answer 17

causes wide spectrum of disease (pharyngitis, conjunctivitis pink eye, GI, hemorrhagic cystitis-inflam of urinary bladder)

in RT, can cause productive infection, persistent infection with virus shedding, or latent infections in lymphoid tissues like tonsils

Question 18

adenovirus-prevention and control?

Answer 18

no adenovirus vaccine for general public. new live attenuated vaccine was approved for military recruits

cidofovir for immunocompromised

Question 19

measles virus symptoms

Answer 19

maculopapular rash
COUGH
CONJUNCTIVITIS
CORYZA
3 C's

photophobia
Koplik spots (inside cheeks, white)

Question 20

complications of measles

Answer 20

otitis media
croup
pneumonia

Question 21

measles virus is of what family

Answer 21

paramyxovirus

Question 22

DNA viruses for respiratory dis

Answer 22

adenovirus

herpesvirus (EBV, CMV, HSV)

Question 23

RNA viruses for respiratory dis

Answer 23

picornavirus (rhinovirus, enterovirus)
coronavirus (coronavirus, SARS, MERS)
orthomyxoviridae (influenza A, B, C)
paramyxoviridae (parainfluenza, RSV, metapneumovirus, measles, Hendra, Nipah)