Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Endocrine Test 2 > Non-Insulin Meds > Flashcards

Non-Insulin Meds Flashcards

1
Q

Secretagogues

A 
SU & Meglitinides
Glyburide
Glipizide
Glimepride
Repaglinide
Nateglinide
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sensitizers

A

Metformin & TZDs
Metformin
Pioglitazone
Rosiglitazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Glyburide Brand Name

A

Diabeta, Micronase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Glyburide micronized Brand Name

A

Glynase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Glipizide Brand name

A

Glucotrol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Glipizide XL Brand Name

A

Glucotrol XL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Glimipiride Brand Name

A

Amaryl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Glyburide Onset and Duration

A

O: 1-60 minutes
D: 16-24 hr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Glyburide Micronized Onset and Duration

A

O: 15-60 mins
D: 12-24 h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Glipizide Onset and Duration

A

O: 30 min
D: 12-24 h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Glipizide XL Onset and Duration

A

O: 2-3 h
D: 24 h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Glimeprided Onset and Duration

A

O: 2-3 hr
D: 16-24 hr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SU Side Effects and Contraindications

A

Weight gain
Hypoglycemia
Sulfa allergy
Renal and hepatic insufficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Efficacy of SU

A

Reduces FASTING and pp levels

Requires working beta cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Repaglinide Brand Name

A

Prandin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Nateglinide Brand Name

A

Starlix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Repaglinide Onset and Duration

A

O: 30 min
D: <4 hrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Nateglinide Onset and Duration

A

O: 15 min
D: 4 hrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Meglitinides Side effects and contraindications

A

Weight gain
Hypoglycemia
Same as SU but no sulfa
Renal and hepatic insuffiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Efficacy of Meglitinides

A

Reduces postprandial glucose levels

Require working beta cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Characteristics of a best response for Meglitinide use

A 
PP levels concern
DMT2 <5 yrs
Mild hyperglycemia
No previous insulin
Cost not an issue
Not obese
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Characteristics of best response for SU use

A

DMT2 <5 yrs
Mild-moderate hyperglycemia
No previous insulin
Not obese

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Metformin Brand Name

A

Glucophage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Metformin Onset and Duration

A

O: Days to 6 weeks
D: Weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Metformin side effects and contraindications

A

Weight loss
GI
Renal insufficiency, iodinated contrast and heart failure (black box)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Metformin Efficicacy

A

Reduces FASTING

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Characteristics of best response in metformin use

A 
Obese
Mild-moderate hyperglycemia
Insulin resistance strongly suspected!!!
1st line!!
CV risk
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Pioglitazone Brand Name

A

Actos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Rosiglitazone Brand Name

A

Avandia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Pioglitazone Onset and Duration

A

O: 4 weeks
D: 4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Rosiglitazone Onset and Duration

A

O: weeks
D: weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

TZDs side effects and contraindication

A

Edema/fluid retention
Weight gain
Hepatic insufficiency
CHF (blackbox)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

TZDs Efficacy

A

Reduces glucose levels by increase sensitivity

34
Q

Characteristics of best response of TZDs

A

Mild hyperglycemia
Cost not an issue
Insulin resistance strongly suspected!!

35
Q

Rosiglitazone Controversies

A

Increase MI

36
Q

Pioglitazone Controversies

A

Bladder cancer

37
Q

GI Glucose Absorption Inhibitors

A

Alpha-Glucosidase Inhibitors
Acarbose
Miglitol

38
Q

Acarbose Brand Name

A

Precose

39
Q

Miglitol Brand Name

A

Glyset

40
Q

AGI MOA

A

Limits breakdown of complex carbs

Decrease PP levels

41
Q

AGI Side effects and contraindications

A

GI (gas)

GI disorders

42
Q

AGI Efficacy

A

Take with food will it decrease PP

43
Q

Characteristics of best response for AGIs

A

Mild hyperglycemia
PP hyperglycemia
Treat hypo with glucose

44
Q

Incretin Systems

A 
GLP-1 Agonists & DPP-4 Antagonists
Exenatide
Lirglutide
Albiglutide
Dularglutide
Sitagliptin
Saxagliptin
Linagliptin
Alogliptin
45
Q

Exenatide Brand Name

A

Byetta

46
Q

Exenatide LA Brand Name

A

Bydureon

47
Q

Liraglutide Brand Name

A

Victoza

48
Q

Dulaglutide Brand Name

A

Trulicity

49
Q

Albiglutide Brand Name

A

Tanzeum

50
Q

Exenatide Onset and Dosing

A

O: 1-2 hrs
D: 12 hrs

51
Q

Exenatide LA Onset and Dosing

A

O: 2-9 wks
D: 7 days

52
Q

Liraglutide Onset and Dosing

A

O: 8-12 wks
D: 24 hrs

53
Q

Albiglutide Onset and Dosing

A

O: 2-5 days
D: 7 days

54
Q

Dulaglutide Onset and Dosing

A

O: 24-72 hrs
D: 7 days

55
Q

GLP-1 Agonists Efficacy

A

Shorter acting: PP

Longer acting: Fasting + PP

56
Q

Characteristics of best response with GLP-1 Agonists

A

Weight loss!!
SQs acceptable
Cost is okay

57
Q

GLP1 Agonists interactions

A

Slowed gastric emptying

58
Q

GLP-1 Agonists side effects and contraindications

A

Nausea
Hypoglycemia
Renal insufficiency, GI disease, acute pancreatitis (black box)

59
Q

Sitaglipitin Brand Name

A

Januvia

60
Q

Saxagliptin Brand Name

A

Onglyza

61
Q

Linagliptin Brand Name

A

Tradjenta

62
Q

Alogliptin Brand Name

A

Nesina

63
Q

DPP-4 Inhibitors efficacy

A

Reduces PP

64
Q

Characteristics of best response with DPP-4 inhibitors

A

With other oral agents

65
Q

DPP-4 Inhibitors side effects and contraindications

A

Hypersensitivites
Hypoglycemia
Renal insuffiencies

66
Q

Sodium Glucose Cotransporters 2 Inhibitors

A

Canagliflozin
Dapagliflozin
Empagliflozin

67
Q

Canagliflozin Brand Name

A

Invokana

68
Q

Dapagliflozin Brand Name

A

Farxiga

69
Q

Empaglifloazin Brand Name

A

Jardiance

70
Q

Canagliflozin Onset and Duration

A

O: 1-2 hrs
D: 24

71
Q

Dapagliflozin Onset and Duration

A

O: 2 hrs
D: 24 hrs

72
Q

Empagliflozin Onset and Duration

A

O: 1.5 hrs
D: 24 hrs

73
Q

Na-Glc CTI Benefits

A

Insulin independent mechanisms
Weight loss
Low risk of hypoglyc
Reduces BP

74
Q

Na-Glc CTI AE and Interactions

A 
Genitourinary infections
Increase potassium
Kidney function reduction
Monitor K with ACI-I/ARBs
CYP inhibitor
75
Q

Na-Glc CTI Precautions

A

Not in T1, severe renal impairment or hypersensitivity

76
Q

Bromocriptin

A 
Cycloset
Dopamine agonists
2 hrs after waking 
With food other wise nausea
Reducation blood glucose very little
High cost
77
Q

Colsevelam

A 
WelChol
Bile acid sequestrant that reduces fastiing
High tablet burden
Little weight gain
Little hypogly
78
Q

How to choose an oral agent?

A 
Obeses (use metformin or GLP1)
Renal insuf (no metformin or glyburide)
Hepatic insuf (no TZD or glipizide)
Heart failure (no TZD or metformin
79
Q

Failure of therapy actions?

A

Mono therapy failure –> add

Dual therapy failure –> add another or begin insulin

80
Q

Insulin should be added if:

A

Failing combo oral therapy (keep sensitizers, wean off secretagogues)
Insitial presentation is hyperglycemia + weight loss

Endocrine Test 2 (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions