4

Question 1

Categories of stem cells

Answer 1

Fertilized zygote–totipotent1. Embryonic stem cell–pleuripotent2. Fetal/perinatal stem cell3. Adult stem cell–multipotent4. Induced stem cell–pleuripotent

Question 2

Induced pleuripotent stem cell

Answer 2

iPS cellProduced by reprogramming of adult somatic cellsRequires transdifferentiation and redifferentiation of fully differentiated cells into pleuripotent cells

Question 3

Types of adult stem cells

Answer 3

1. mesenchymal/stromal2. hematopoetic3. neural

Question 4

what is the ultimate validation of pluripotency seen in embryonic and induced stem cells

Answer 4

germline transmission

Question 5

where do adult hematopoetic stem cells come from?

Answer 5

Bone marrowautogenous/allogeneictarget cells for bone marrow transplantation

Question 6

where can mesenchymal/stromal stem cells come from?

Answer 6

Bone marrow, adipose tissue, umbilical cord, muscle, and other tissue (cartilage, tendon, tonsil, dental pulp)function to secrete trophic factorsimmunotolerant

Question 7

T/FThe fate of a pluripotent cell to differentiation is unidirectional

Answer 7

FALSEinduced stem cells (iPS cell) can undergo transdifferentiation and re-differentiation reprogramming where a fully differentiated cell can be induced into a pluripotent state.