Chapter 43- Hepatitis Flashcards
Describe Hepatitis A
picornaviridae. non enveloped ss (+) RNA
Hepatitis A incubation time
about 1 month
Hepatitis A pathogenesis
Virus produced in hepatocytes and Kupffer’s cells. Virus released into bile and shed through stool. Large quantities shed about 10 days before jaundice. Does not cause chronic liver disease, and rarely fatal.
Diagnosis of Hepatitis A
serological tests -> anti-HAV IgM
Treatment and prevention of Hep A
Interrupt the fecal-oral spread. immune serum globulin (pooled): during incubation. Inactivated (killed) HAV vaccine
Describe Hepatitis E
Icosohedral, non enveloped, + sense ss RNA. Hepeviridae.
Describe Hepatitis B
Hepadnaviridae. small, enveloped, partially ds DNA
HB_Ag’s of Hepatitis B
HBsAg- envelope protein
HBcAg- core Ag
HBeAg- minor Ag
Hepatitis B incubation time
2-3 months
High, moderate and low levels for transmission
High- blood, serum
Mod- semen, vaginal secretions, saliva
low- urine, feces, tears, sweat
Complications from Hep B
primary hepatocellular carcinoma. cirrhosis. carrier, often for life.
Diagnosis of Hep B
Clinical symptoms, liver enzymes, detection of HBsAg, alphaHBsAb, and alphaHBcAb
Hepatitis B vaccine’s
1) 3 dose series
2) 2 dose adult series
Babies born to mom with hep b infection.
Give immunoglobulin
Describe Hepatitis D
Deltavirus. defective ss (-) RNA. Envelope protein composed of HBsAg. requires helper function of HBV to replicate.
