3.1 Introduction Targeted Therapy Flashcards
1
Q
What are the two types of molecules involved in targeted therapy?
A
- Small molecule
- Large molecule
2
Q
What is the difference between small and large molecules?
A
- Small molecules can enter the cell to exert their effect
- Large molecules canot enter the cell, and exert their effect on extracellular receptors
3
Q
How are small molecule drugs administered?
A
Oral
4
Q
How are large molecules administered?
A
Parentral
5
Q
Which type of targeted therapies are small molecules?
A
Tyrosine kinase inhibitors?
6
Q
Which type of targeted therapies are large molecules
A
Monoclonal antibodies
7
Q
What is the suffix typically seen with tyrosine kinase inhibitors?
A
Nib
8
Q
What is the suffix typically seen with monoclonal antibodies?
A
MABs
9
Q
Can small & large molecules target the same molecular target
A
- Yes, if you take EGFR for example…
- Cetuximab targets the EGFR receptor on the outside of the cell.
- Erlotinib can target EGFR inside the cell.
