3.1 RPR

Question 1

A sexually transmitted infection that is caused by one of the member of Spirochaetaceae?

Answer 1

Syphilis

Question 2

Causative agent for syphilis?

Answer 2

Treponema pallidum

Question 3

One of the members of Spirochaetaceae that is the agent of yaw?

Answer 3

T. pallidum subspecies pertenue

Question 4

One of the members of Spirochaetaceae that is cause of nonvenereal endemic syphilis?

Answer 4

T. pallidum subspecies endemicum

Question 5

One of the members of Spirochaetaceae that is the agent of pinta?

Answer 5

T. pallidum subspecies carateum

Question 6

Lenght of treponema pallidum?

Answer 6

6 to 20mm

Question 7

width of T. pallidum?

Answer 7

0.1 - 0.2 mm

Question 8

How many coils of Treponema pallidum?

Answer 8

6 to 14 coils

Question 9

Organisms in this family have a natural reservoir such as lake (environment) and can multiply within a living host

T or F

Answer 9

F

This bacteria have no natural reservoir and MUST multiply within a living host

Question 10

MOT of T. pallidum includes:

Direct contact and Sexual transmission

Direct contact is the primary mode of transmission?

T or F?

Answer 10

F

Sexual transmission is the primary mode of transmission

Question 11

Treponemes are rapidly destroyed by heat, cold, and drying out

T or F

Answer 11

T

Question 12

What is the initial lesion during primary stage called?

A painless, solitary lesion characterized by raised and well-defined borders

Answer 12

Chancre

Question 13

Chancre develops between how many days? What is the average?

Answer 13

10 - 90 days

21 days average

Question 14

Chancre can be seen on the penis of a woman and in the vagina specifically in the cervix of a man?

T or F

Answer 14

F

…. self-explanatory na ito….

Question 15

Primary stage last for?

a. 1-4 weeks
b. 10-90 days
c. 1-6 weeks
d. 21 days

Answer 15

c

Question 16

What will happen if the initial chancre is left untreated?

Answer 16

Systemic dissemination

(25% of this case)

Question 17

Secondary stage is usually observed about _____ months after primary chancre disappears

Answer 17

1 - 2

Question 18

This stage is characterized by a lack of clinical symptoms

Answer 18

Latent stage

Question 19

what individual is an exception to latent stage of syphilis?

a. Pregnant
b. HIV patient
c. Children
d. Elder

Answer 19

a

May pass the disease on the fetus

Question 20

The 3 major manifestation during teritary syphilis includes:

Cardiovascular disease
_________________
_________________

Answer 20

Gummatous syphilis
Neurosyphilis

Question 21

Are localized areas of granulomatous inflammation that are most often found on the bones, skin, or subcutanerous tissue?

Answer 21

Gummas

Question 22

Tertiary syphilis typically occurs most other between _______________ following the secondary stage?

a. 10 -30 years
b. 10 - 30 days
c. 10 - 30 hours

Answer 22

a

Question 23

This stage consist of symptoms of generalized lymphadenopathy,
malaise, fever, pharyngitis and a rash on the skin and mucuous
membranes?

Answer 23

Secondary stage

Question 24

This stage may involve CNS

a. Primary
b. Secondary
c. tertiary

Answer 24

Secondary stage

Question 25

A non-treponemal test that are based on flocculation reaction and a presubptive serologic screening test for syphilis?

Answer 25

Rapid plasma Reagin Test

Question 26

Serum of a person with syphilis contains a non-specific anti-lipid antibody, this termed as?

Answer 26

Reagin

Question 27

Fatty substances which are release, combined with the protein from Treponema pallidum to form an antigen which stimulates the body to produce antibodies against both the body’s tissue lipids (non-treponemal) as well as the Treponema pallidum protein (specific or treponemal) T or F

Answer 27

T

Question 28

RPR test detects the non-specific antilipid antigen and is referred to as a treponemal test for syphilis T or F?

Answer 28

F Non treponemal test

Question 29

A non-treponemal slide agglutination test for the Quantitative detection of reagins in human serum T or F?

Answer 29

F Qualitative

Question 30

What makes the reaction in RPR test visible?

Answer 30

Charcoal

Question 31

The known RPR antigen consists of_____,_____,_____ that is bound to charcoal particle

Answer 31

Cardiolipin lecithin Cholesterol

Question 32

NOTE: If the patient has syphilis, the antilipid antibodies (reagin) in the serum will cross-react with the known RPR lipid antigens and will give a visible clumping of the charcoal particles

Question 33

Plasma and serum can be used as a sample? T or F?

Answer 33

T Plasma can be used as a sample provided that sample should be centrifuged to remove fibrin before testing

Question 34

When plasma is used as a sample, centrifuged is done to remove?

Answer 34

fibrin

Question 35

Not suitable for testing: Hemolyzed, lipemic and high concentration of bilirubin T or F

Answer 35

T

Question 36

RPR test result is reported as?

Answer 36

Reactive or non-reactive