Week 4: Publishing & Communcation problems Flashcards

1
Q

Common misconception regarding scientific publishing?

A

‘Scientists get paid for published work’ This is incorrect.
Scientist have to pay to get there work published.

It is common to pay a fee – for colour, you pay for open access, length of article, number of authors etc Severe limitation for people from underfunded labs

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2
Q

The process of publication:

A
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3
Q

Why is science published?

Give three examples of why informing/educating the public is important

A

Most research I publicly funded, there public have right to the information
Duty to inform/correct bad information

  • CSI effect
  • Fluoride in Florida
  • L’aquila earthquake

Publications are how scientists are measured: this is the product of a Scientist

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4
Q

What is the CSI effect?

A

After CSI became a populer show, the legal industry noticed that jury trials were going badly. Prosecutors were not getting convictions on obviously guilty verdicts “well they didn’t have the same evidence as they produce on CSI – not enough forensics”

In reality forensics isn’t used very often

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5
Q

What is the Florida fluoride controversy?

A

Fluoride is found in drinking water. Since the 1930s almost all drinking water supplies have had fluoride added to it in most developed countries. This has been of controversy for nearly 90 years. In the early 20th century we began to add fluoride to water because it was considered a miracle preventative to tooth decay – people who couldn’t afford to see the dentist – would not need to go because of the water with fluoride added in it 10 or 15 years – the controversies and conspiracies came out there has never been a side effect from water. The only side effect is that in some children in there children’s teeth they may get some white dots – which is extra enamel. It was labelled a communist conspiracy – when communism lost its fear factor effect in the US it was replaced by new conspiracies began to arise. Most recently in October 2011 in Florida, there was a vote to eliminate fluoride water supplies, why? Because the voting commissioner was beset that “my citizens who viewed water fluoridation as an unnecessary, even malevolent form of government intervention” according to an article in the Tampa bay Times some accused the board of trying to medicate them into submission some warned that it was a Nazi based policy designed to kill off the undesirables. Some claimed that there ailments stemmed from the drinking water. One mother described it as “terrorism” Fluoride… in your drinking water which, as far as we know, has done nothing but improve teeth decay rates. They took fluoride outside the drinking water. This is a case of complete public miscommunication – scientists have a duty to try and change those kinds of things. Climate change, land management – scientists have a duty to convey information to public.

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6
Q

What happen to scientist who failed to predict the L’Aquila earth quake in 2009?

A

Earth quakes took place In 2009 there was a massive earthquake – the scientists were convicted of man slaughter. They were accused of not informing the public, and they went to jail – for not warning the public strenuously A trial, which lasted from September 2011 until October 2012, found six scientists and a former government official guilty of involuntary manslaughter. According to the prosecution, they had spread “inaccurate, incomplete and contradictory” statements after preliminary tremors could be felt on the days before 6 April 2009. While scientists were found guilty for failing to give adequate warning.

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7
Q

The risk in making public statements?

What is the risk?

A

There is a risk in making public statements, example L’Aquila – but scientists are asked to give their opinion on things, however people will assume a certain level of authority in what you say, this could lead to misunderstanding

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8
Q

How are academics measured?

A

REF (Research excellence framework) – once every 7 years, evaluation of academics and universities, measured on 3 things (1 is grant income – but also Impact Factors and Publication Rate)

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9
Q

What happens to rejections? Where to papers then go?

A

Dr Elizabeth Clare likes to call this ‘the publication river’

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10
Q

Calcagno et al. 2012 Surveyed 932 biology journals for two years, looking at 80,748 articles histories (37% response rate) What was found?

A

*75% of articles are published in the first journal they are submitted too. *Higher impact journals are frequently first choices by authors, authors move from high to low impact, higher impact journals tend to publish more resubmitted articles *Higher impact is in the middle, you try to move it between the highest ranked journals.

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11
Q

Impact factors guide submissions

A

Higher impact journals publish fewer first submission articles, Nature and Science attract highest impact

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12
Q

Most papers are subjected to single or double blind review What is a single-blind review?

A

reviewer knows who they are reviewing, but the scientist doesn’t know the reviewer

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13
Q

Why does the reviewer wish to be anonymous?

A

Well if someone writes a critical review they may not want the scientist to know, to avoid facing retribution. Younger academics are more likely to remain anonymous, whereas a senior academic will sign it because there careers are more well established.

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14
Q

What are open reviews?

A

Everybody is known to everybody else – corruption can enter into the system

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15
Q

Corruption can enter peer review. Give three examples:

A

2011 Nature reviews drug discovery reported that 2/3 of 67 key papers (2008-2010) had results that could not be duplicated. 2012 35 papers retracted from Journal of Enzyme inhibition and medical chemistry immunopharmacology and immunotaxicology due to fake e-mail address rings. July 8th 2014 60 papers retracted from the Journal of Vibrational Control base on corrupted review and a review ring. A reviewer name, is when somebody registers with different names and emails in the circle. So you can register name 10 times, with 10 different pseudonyms, then journal article submitted – when editor asks can you suggest reviewers, the scientist would suggest themselves under the pseudonym names.

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16
Q

Gaming the system How were they discovered?

A

Reviews coming back within a couple of hours – ludicrous

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17
Q

Irreproducible results What are the most common issues?

A
  1. Poor experimental design 2. Emphasis on making provocative statements 3. Don’t report basic elements of design 4. Secret sauce effect (waiting for patent approval) 5. Academy member effect; you can get a member of the academy to communicate their paper for them (shut down)
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18
Q

Open access Data In genetics we must deposit all DNA data in a public repository.

A

ONLY geneticists are required to put their raw data somewhere it can be found – this is changing. Partly because of the problems we are seeing in some papers. Limitations to this DNA is not raw data – as it is an interpretation of what comes off a sequencer but it is as raw as we normally get.

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19
Q

Dryad – if you publish an article in something like Molecular Ecology…

A

…they will insist that all raw data are produced into Dryad – there are cases for safety restrictions

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20
Q

Public library of science policy

A

added as supplements to articles, lack of data has led to costly (suspected) fraud

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21
Q

What are open access papers?

A

this is an internet invention, it has two effects democratizing science or fraud? Open access is a resource for everyone, and anybody can read it – you don’t have to have a uni access. Normally you pay a heavy fee for this – it makes it a resource for everyone – online only model – some funders ONLY want open access = higher impact

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22
Q

Predatory publishers -

A

Pay for access model – reviewers and editors are volunteers – but money needs to be generated for business side this has led too

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23
Q

Jeffery Beall’s story

A

librarian he gets asked to join an editorial board, this is a prestigious request. There are BAD requests! Beall’s list - made a list of publishing companies that he didn’t believer were real – they contact scientists asking them to publish the article to there journal and then they publish it They don’t have peer review they are just making money of scientists desperate to publish there work Academics get emails every day

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24
Q

Beall’s list

A

he has research publishing companies that he determined are predatory – of the them is - OMICS runs thousands of journal publishing companies and organises conferences, arguably they are huge frauds. He published their name and they sued him for 3 million dollars for slander.

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25
Q

Plenty of case studies for OMICS doing bad things

A

Entomology - 2013 one of the most prominent conferences (Entomology 2013), many people registered thinking it’s the one without “–“ Identity fraud, they have cases against them from PubMed

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26
Q

Who is afraid of peer review?

A

Experiment in peer review – scientist generated papers with clearly inaccurate and submitted it to journal publications. 157 accepted – MOST places he submitted it too took it immediately (in the open access world) only 97 rejected it. Rule of thumb any journal that contacts you – isn’t a good one

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27
Q

Open access problem – this has become a huge business

A

Good in making science publically available – but has a bad side

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28
Q

What is Professional Editing?

A

Nature will edits your article for a cost – BUT – not guarantee that you will be published Many private companies that will edit reformat and reanalyse your data for you English langue translation services, publication language is almost always English, many times recommended linguistic assistance

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29
Q

Alternatives to Professional Editing

A

Macmillian Scientific communication offers editorial services on content, structure and presentation Authors can ask for recommendations from journals – some services may provide comments on experimental design – is that ethical? Should editors get credit or be disclosed? New England Journal of Medicine – requires that authors disclose any formal editing system – this may be a response to allegations of “ghost-writing” in medical research – companies publishing papers by borrowing the names of an academic to publish under

30
Q

What is Plagiarism?

A

Plagiarism of other people’s work Plagiarism of your own work Plagiarism by journal themselves

31
Q

Self-Plagiarism – a lesser evil?

A

Prof Smith found to have self-plagiarized up to 20 papers by copying sections from previous work, investigations led to 3 papers to be retracted many of the targeted publications were republications of conference proceedings – is that wrong? What constitutes self-plagiarism? Same things you worry about… References – use of the same reference continually? Methods – how many ways are there to state PCR mix? Results – what if these are

32
Q

Editorial Coercion; We’ll publish if…

A

During revisions, scientists are frequently requested to include additional citations Coercive Citations Give no indication that the manuscript lacked something, make no specific suggestions on what should be cited, but does guide the author to add citations from the editor’s journal “you cite Leukemia. Consequently we kindly ask you to add references of articles published in Leukemia”

33
Q

Survey of 6672 academics, asked would they add references?

A

175 journals named as coercers, one journal named by 49 different people

34
Q

An Alternative for the Internet Age

A

Self-review – online community feedback

35
Q

Games we play

A

Self-citation - increases your own visibility increases your personal indices Online early – articles published a year ahead of print version before citation counts on indices – can sneak an extra year in there

36
Q

For the most part – does the system work?

A

The system really does work and most of us never face anything controversial. However, the academic publishing world is complex and sometimes feels full of shady practices and questionable methods. When doe this rise to the level of public controversy and outright fraud?

37
Q

Give 5 examples of controversy and fraud?

A
  1. Endosymbiosis… yeah right… 2. Velvet worms… how to shut down publishing 3. Arsenic life… look before you leap 4. Piltdown Man 5. Vaccines… fear fear fear… and more fear…
38
Q

What is the endosymbiotic theory?

A

The theory that the reason we exist as multicellular life is because there is mitochondria inside almost every single cell – and that that mitochondria was once a free living bacteria this is absolutely known to be true with copious amounts of evidence. As oxygen levels rose anaerobic eukaryotes “consumed” an aerobic bacteria – endosymbiotic theory assumes that eukaryotes came first that the mitochondria came from and oxygen loving bacteria

39
Q
  1. Endosymbiosis Who proposed this theory?
A

This theory was proposed in 1967 by Dr. Lynn Margulis,

40
Q

Initially endosymbiosis theory was rejected…

A

It was perceived as a crazy idea that simple bacteria were incorporated into early cells and became organelles. Her paper on this theory was rejected by at least 12 different journals and called preposterous - it was published in a small journal called “Journal of Theoretical Biology”. That finally took it because every other journal called it crazy. 11 year later Schwartz and Dayhooff published a paper which concluded she’d been right all along.

41
Q

What was the problem with Dr. Lynn Margulis after endosymbiosis?

A

The problem is that it didn’t stop there, many of her theories remain controversial – some of them are now considered really, really out there.

42
Q

What controversial ideas did Dr. Lynn Margulis become a proponent off?

A
  • Gaia hypothesis; the idea that earth is a self-regulating organism, she would argue that the earth would adapt to suit us – bacteria pumped out a lot of oxygen - Dismissal of Population Genetics - Flagella came from spirochetes - no evidence for this - HIV doesn’t exist - Symbiosis drives speciation - “I don’t consider my ideas controversial, I consider them right” – Dr. Lynn Margulis
43
Q

What impact did Dr. Lynn Margulis have on the publication industry in PNAS?

A

She was a member of the academy. Communicating papers idea, a few years before she died a paper emerged that made a bizarre claim that a caterpillar and a butterfly were two different things and that metamorphosis is an accidental mating between a velvet worm and a flying insect

44
Q

This was published in PNAS “Caterpillars are larvae of lepidopterans, hymenopterans, and mecopterans (scorpionflies). Grubs and maggots, including the larvae of beetles, bees, and flies, evolved from caterpillars by loss of legs..

A

Metamorphoses did not originate solely by accumulation of random mutations Members of the phylum Onychophora (velvet worms) are proposed as the evolutionary source of caterpillars and their grub or maggot descendants” Butterfly hybrids? This is a onychophora – it superficially looks a little like a worm or caterpillar but it has no evolutionary relationship from either of those groups. It is very distantly related – the paper argued that this onychophora mated with a flying butterfly – but there is no evidence for this In fact if you simply compared some DNA you would realise there is not onychophora in a butterfly

45
Q

This appeared in PNAS one of the premier biology journals, it was immediately under attack … “PNAS… permits elected members of the Academy to promote papers they like by “communicating” them and adjudicating the reviews” (Prof. Jerry Coyne of the University of Chicago) “[PNAS] has halted the print publication of a controversial scientific paper, saying its investigating the conditions under which it was ushered through peer review” The Scientist

A

It is suspected that what Dr Lynn did is collect a range reviews and only solicited them with the paper

46
Q

Reactions to PNAS publishing Dr Lynn

A

“better suited for the National Enquirer than the National Academy than the National Academy.” – Scientific American “Bigwig” ushered “nonsense” paper into top journal” – Times Higher Education The editor of PNAS “The matter appears extracted from a science fiction novel but has grave implication. This paper has fallen through the cracks of the review process of one of the most prestigious scientific journals, and this has not passed unnoticed. Online debates have erupted between those appalled that such article has appeared in a scientific forum and those who feel that scientific debate requires that ll ideas, no matter how ill-formed, be discussed. But we should ask whether an individual can propose any theory, no matter how unsupported that idea may be, and demand that others do the works to test it scientifically” Gonzalo Giribet-PNAS

47
Q

Life is made up of carbon, hydrogen, oxygen, nitrogen, sulphur and phosphate We know this because every single life form we have ever found follows these rules (inductive reasoning) – so we conclude that that is how life works. That is inductive, what is the probability that the next life form we find follows the rule? What is the arsenic based life story?

A

But it is possible to find something that does not follow the rules – the arsenic story is a chemical one (Phosphate and Arsenic have very similar properties) similar atomic radius and electronegativity Biological for of P is PO43- which is similar to AsO43- but this is how it kills you because it is so similar it can substitute in your cells and can kill you In Eastern California, we have Mono Lake this is a toxic soup of salt, arsenic and it is alkaline – scientists went out to try and find life They found bacteria called GFAJ-1 (details not important) they grew it in some media and the line at the bottom of the graph shows it growing without anything the middle line shows growing with arsenic in the top is phosphate This appears as though they prefer phosphate but this is evidence to argue that it could grow in arsenic only But they argued it was substituting arsenic for phosphate in the DNA allowing it to grow They called it arsenic based life

48
Q

The Headlines of ‘arsenic-based’ life

A

“Arsenic-eating microbe may redefine chemistry of life” “a biochemistry… which could be used by organisms in… extreme environments…or even on other planets”

49
Q

The responses of ‘arsenic-based’ life

A

“NASA press release drew media attention with claims of an astrobiology finding that will impact the search for evidence of extra-terrestrial life” “Microbe gets toxic response” “Scientists are questioning the finding and taking issue with how it was communicated to non-specialists”

50
Q

Open Research Approach – Rosie Redfield – UBC She decided that she was going to recreate there experiments but not only was she going to try to recreate it but she was going to do it only so that everybody could watch her. Over

A

Over time she ran the exact same NASA experiments and every day she published the results on her website. Her results showed that When grown in a media with both arsenic and phosphate they contain no arsenic at all, a second paper; can grow in very low phosphate conditions but NOT in its absence Their conclusion is that the better story is how they survive in arsenic toxicity – this is the interesting thing – that they don’t die – But it is NOT arsenic based life

51
Q

Author’s Response to Rosie Redfield

A

“We are thrilled that our results are stimulating more experiments from the community as well as ourselves” “We do not fully understand the key details of the website experiments and conditions. So we hope to see this work published in a peer-reviewed journal, as this is how science best proceeds” They didn’t say sorry we are wrong – just said great more research is happening Media events overshadowing results

52
Q

What is the ‘Piltdown Man’?

A

Piltdown man was the first supposed hominid found in England, found in Essex – the black bits are the bone fragments found and the white bits are the reconstructed parts. It was constructed in the early part of the search for human remains, very early 1900’s, Charles Dawson in the middle.

53
Q

The discovery of hominid fossils was just starting to take off, Neanderthal had just been found, Homo heidelbergensis had just been found. But there was virtually no evidence out there for how human evolution had occurred, and so there was this frenzy around Europe to find this fossils and England had none. There was a mixture of those who didn’t know what evolution was in that Darwin was fairly newly accepted and that England wanted to be first to make a claim to have had the early ancestors of the British. Charles Dawson was an antiques collector, and the story goes in early 1900s he was walking through Essex and a farmer who was digging a ditch handed him a fragment of a skull and he spent some time examining this and then within a couple of years he announced the discovery of the fossil remains of what he called peltdown man. In east Sussex he collaborated with a geologist from the British Museum, and French anthropologist – he said the skull was human like and that the brain was much smaller – they produced a jaw – the fossil declared a missing link…The skull was a medieval human fragment, the jaw was from an orangutan, the teeth were chimpanzee.

A

One of the key missing link fossils for about 50 years because it liked humans to chimps – it claimed that humans had evolved from chimanzee’s which is of course not true, we shared a common ancestor with them. We did not evolve from them, but this was evidence for chimpanzee ancestor, one of the key controversies were what would the canine teeth look like, they said that would be very important in understand how the teeth evolved, Dawson and the gang went back, and sure enough brought back the canine teeth.

54
Q

Piltdown was a fraud The problem was that as more hominid remains were found, Piltdown didn’t. A thorough investigation eventually revealed it was a fraud. The skull was a medieval human fragment, the jaw was from an orangutan, and the teeth were chimpanzee teeth.

A

The bones had been stained to make them look old, teeth filed own to disguise their appearance – this was a deliberate fraud.

55
Q

Who were the suspects to the piltdown man fraud?

A

Suspects? Dawson – it appears most of his finds were faked, 38 of his other specimens show clear evidence of forgery, some in the same way as the Piltdown fragments Martin Hinton – when he died they found a trunk in his office that contained all the material to colour the bone and several obvious experiments Sir Arthur Conan Doyle – has been implicated as a potential cause of this, he had an axe to grind against the community and some people claim that some of his Sherlock Holmes novels had clues in it.

56
Q

The second Hoax hypothesis;

A

Dawson created the first problem – deposited the first jaw but then other people went and put other bones there to try to make him admit his lie

57
Q

What was the effect of Piltdown?

A

Remember that at the time, we knew almost nothing about human evolution and evolution itself was a relatively new concept. Piltdown got people interested, ironically Piltdown provided real evidence for human evolution and led to a real hunt for other remains – this led to some of the greatest hominid discoveries of all time Lucy, found in Africa in the 60’s, since then there has been mass race to find bones – although Piltdown was a fraud it created enough interest to find real remains – a fraud that had a benefit in the end

58
Q

What do vaccines rely on?

A

Vaccines rely on things called herd immunity, the level of population immunity above which sustained transmission is unlikely ~85% most of the time. Vaccination is a “firewall”, essentially people who are protected don’t allow the spread,

59
Q

How many disease have we eliminated with vaccines?

A

Smallpox Rinderpest

60
Q

Smallpox

A

Two forms - Major 35% death - Minor 1% death - 80% in children Existed in humans for 12 thousand years, killing half a million Europeans annually, caused 1/3 of all blindness cases

61
Q

Earliest vaccines were used in India and China and may be thousands of years old, WHO initiate a campaign of worldwide vaccination in 1967. How did they do this?

A
  1. Aggressive quarantine 2. Search for infected 3. Mass vaccination Having considered the development and results of the global program on smallpox eradication initiated by WHO in 1958 and intensified since 1967. Declares solemnly that the world and its peoples have won freedom from smallpox, which was a most devastating disease seeping in epidemic form through many countries since earliest time, leaving death, blindness and disfigurement in its wake and which only a decade ago was rampant in Africa, Asia and South America
62
Q

Value of Vaccines

A

Since world war 2 went from 5% to 70% – Smallpox killed 2 million a year unIl the late 60s gone by 1979 – Polio fell from 300,000 per year in 1980s to 2000 in 2002 – two thirds of all countries have eradicated neonatal tetanus – since 1974 measles deaths dropped form 6 million to less than 1 million – Whooping cough cases fallen from 3 million per year to less than 250,000 – Diptheria declined from 80,000 in 1975 to 10,000 – Hib meningitis in Europe declined 90% in ten years

63
Q

Why do people not vaccinate?

A

Religious reasons, medical reasons, age and some areas there is a conscious objection law

64
Q

Vaccine controversies; Whooping Cough

A

Pre-vaccine, whopping cough epidemics appeared every 2-5 years. Immunization reduced incidence 157%, controversy of brain injury, concern about the safety of the DTP vaccine in the 70s left to a conversion to a new DTaP version in the 80s but it was less effective – whooping cough is now epidemic

65
Q

Who was Wakefield?

A

Andrew Wakefield was a surgeon – in the early 90s he suggested the measles caused Crohn’s disease, in the mid-90s he suggested the measles vaccine caused Crohn’s disease. His research was shown to be wrong in 1998. In 1995 he was treating a boy with Chron’s disease who also had autism, he hypothesized a link between gastrointestinal disease and autism and “environmental triggers”. He had N=12 (12 children). Of those 12, only 8 had been vaccinated (n=8), the paper stated that non causal connection was known But before publication he had a press conference, he made media statements calling for an all out ban on MMR vaccines, citing it as a moral issue. He even went so far as to state that three vaccines at once was the cause and recommend separate of vaccines. How is this similar to the Encode effect?

66
Q

What happened after Wakefield made his claims?

A

In the end, Serious conflicts; The Sunday Times 2004 1. The children in the original paper were recruited by a lawyer suing the MMR manufactures 2. The hospital received £55,000 from the lawyer to do the research 3. Wakefield received £400,00 The Lancet retracted the paper, 10 of the 12 co-authors published formal retraction, Wakefield lost his license to practice medicine. Subsequent studies based on half million children have demonstrated vaccinated children have no higher prevalence of autism, and might even have a lower prevalence. So there is no evidence for a causal role, but what has the fall out been?

67
Q

UK Results of MMR vaccination

A

MMR vaccination was 92% in 1955 – above the herd effect requirement, MMR vaccination fell to 80% in England and an astonishing 58% in London in the space of only 5 years Most parents cited “the link” as their reason for not vaccinating their children, as recently as 2002 1/3 of health care providers in New Zealand were not sure about the validity of “the link”

68
Q

Measles isn’t the biggest threat What should we be more worried about?

A

We should be more concern about rubella, which causes blindness, disfigurements, deafness … if a woman catches it whilst she is pregnant

69
Q

Public Perception - Wakefield Media influence

A

About even weight in media was given to the Wakefield statements and the actual complaints, thus when survey the public thought it was actually a “controversy” in science A similar scare in the 90s suggested MS was cause by a vaccine – so why is this one still going

70
Q

Internet effect of MMR due to Wakefield

A

Lack of concern – we haven’t seen them to be scared of them Media attention – always trying to give a balanced view, but the evidence is NOT balanced! The media is playing the wrong side for relief (equal coverage) Delayed effect – you have no idea if your immunisation, don’t see cause and effect relationship Identifiable victims – people are allergic to vaccines Lack of target – science cannot provide alternative target we do not know what causes something, we do not know the cause Fear of the rare event – we all fear the odd outcome, rare events are easier to be scared off Can we change attitudes? Surprisingly…no 4-intervention study, Google “Penn and Teller on VaccinaIon”

71
Q

Publications are how scientists are measured

A

Publications are how scientists are measured

This is the product of a Scientist – productivity of scientist is measured by this means.