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YEAR 1 Pharmacolgy > Targets For Drug Interactions > Flashcards

Targets For Drug Interactions Flashcards

0
Q

Lock and key mechanism targets…

A

Cell membrane, nucleus or cytoplasm

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1
Q

Drugs bind to target tissue to produce a….

A

Response

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2
Q

Some drugs target ion channels causing them to…

A

Open or close.

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3
Q

Insulin targets…

A

Carrier molecules on cell membranes.

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4
Q

Some drugs alter the final result when they bind to….

A

Enzymes or DNA

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5
Q

Other drug targets include…

A
  1. Bacteria
  2. Viruses
  3. Fungi
  4. Amoeba
  5. Parasites, eg, worms.
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6
Q

Aspirin and Viagra bind to…

A

Enzymes.

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7
Q

Salbutamol and beta-blockers bind to…

A

Receptors.

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8
Q

Local anaesthetics and benzodiazepines bind to…

A

Channels on cell membranes.

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9
Q

Omeprazole and cocaine bind to…

A

Carrier molecules.

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10
Q

Steroids bind to…

A

DNA.

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11
Q

Penicillin and other antibiotics bind to…

A

Foreign proteins.

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12
Q

What binds to a receptor causing a response to occur?

A

An agonist.

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13
Q

What does an agonist sometimes do?

A

Mimic chemicals found in the body, eg, salbutamol mimics adrenalin in an asthma attack.

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14
Q

What binds to a receptor to stop other chemicals from producing a response?

A

An antagonist.

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15
Q

An example of an antagonist is…

A

A beta-blocker.

16
Q

How long does an antagonist last?

A

A long time, maybe even forever.

17
Q

Correct order of a response being triggered…

A

Drug binds to receptor—-> Activation of 2nd messenger—-> Cascade of enzyme reactions—-> RESPONSE OCCURS.

18
Q

Nuclear receptors….

A

Lipid soluble steroids dissolve in nuclear membrane.

19
Q

Cellular response to drugs….

Contraction?

A

Muscle cells.

20
Q

Cellular response to drugs….

Secretion?

A

Glands.

21
Q

Cellular response to drugs….

Excitation?

A

Nerve cells/ muscle cells.

22
Q

Cellular response to drugs….

Inhibition?

A

Nerve cells.

23
Q

Cellular response to drugs….

Interruption of cell cycle?

A

Tumour cells.

24
Q

What is potency?

A

How much of a drug is needed to produce a certain response in a certain person.

25
Q

If a drug has a high potency…

A

Only a small dose is required to produce a response.

26
Q

A smaller dose is…

A
  1. Cheaper
  2. Easier to administer
  3. Will have less side effects for patient.
27
Q

On a dose-response curve a bigger dose will cause a…

A

Bigger response.

YEAR 1 Pharmacolgy (5 decks)

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