3.2c - Experimental Design Flashcards

1
Q

The independent variable is…

A

the one you change

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2
Q

The dependent variable is…

A

the one you measure

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3
Q

Independent and dependent variables can be…

A

continuous or discrete

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4
Q

Experiments involve the manipulation of the…

A

independent variable by the investigator

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5
Q

The experimental treatment group is compared to…

A

a control group

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6
Q

Simple experimental designs have…

A

one independent variable

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7
Q

Multifactoral experimental designs have…

A

more than one independent variable

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8
Q

A benefit of simple experiments is that…

A

the control of laboratory conditions allows simple experiments to be conducted more easily than in the field

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9
Q

A limit of simple experiments is that…

A

their findings may not be applicable to a wider setting

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10
Q

A benefit of multifactoral experiments is that…

A

they are more relevant to complex biological systems

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11
Q

A limit of multifactoral experiments is that…

A

they are more complex to analyse and require careful experimental design and complex statistics for valid conclusions to be drawn

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12
Q

In an experiment, investigators may use groups that already exist so that…

A

there is no truly independent variable

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13
Q

In observational studies the independent variable is…

A

not directly controlled by the investigator, for ethical or logistical reasons

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14
Q

Observational studies are good for…

A

detecting correlation

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15
Q

Observational studies are less good for…

A

determining causation because they do not directly test for a hypothesis

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16
Q

Causation exists if…

A

changes in the values
of the independent variable are known to cause changes to the value of the dependent variable

17
Q

Other variables (confounding variables) besides the independent variable may affect the dependent variable due to…

A

the complexities of biological systems

18
Q

Confounding variables must be held constant if possible, or monitored so…

A

that their effect can be accounted for in the analysis

19
Q

Any change in confounding variables any affect…

A

in the validity of any observed change in the dependent variable

20
Q

What can be used in cases where confounding variables cannot be easily controlled?

A

a randomised block design

21
Q

Randomised blocks of treatment and control groups can be distributed in such a way that…

A

the influence of any confounding variable is likely to be the same across the treatment and control groups

22
Q

Control results are used for…

A

the comparison with the results of treatment groups

22
Q

Controls the determine the…

A

validity of any change in the dependent variable

23
Q

What 2 controls can be used in experiments?

A

positive and negative

24
Negative controls...
provide results in the absence of a treatment eg placebo
25
Positive controls...
check that the system can detect a positive result when it occurs
26
Placebos can be included as a treatment without...
the presence of the independent variable being investigated
27
Placebo effect is...
measurable change in the dependent variable as a result of a patient's expectations, rather than changes in the independent variable
28
In vitro refers to...
the technique of performing a given procedure in a controlled environment outside of a living organism
29
3 examples of in vitro experiments
- cells growing in culture medium - proteins in solution - purified organelles
30
In vivo refers to...
experimentation using a whole, living organism
31
An advantage of an in vitro study is...
that it is easily controlled
32
A disadvantage of an in vitro study is...
that its relevance may be limited in vivo
33
An advantage of an in vivo study is...
that it allows possible side effects to be seen
34
A disadvantage of an in vivo study is...
that it can be unethical