pediatric thyroid

Question 1

catalyzes the binding of DITs to form T4

Answer 1

thyroid peroxidase

Question 1

Newborn hypothyroid screening

caveats

Answer 1

typically elevated TSH

TSH surge at birth causess false positives
TSH screening does not detect central hypothyroidism

Question 2

congeital hypothyroidism presentation

Answer 2

most asymptomatic

slow lethargy

hoarse cry

constipation

macroglossia

umbilicle hernia and large fontinels

Question 4

most common underlying reason for congential hypothyroidism

Answer 4

failure of gland to form properly (absent, ectopic, or dysplastic gland)

Question 5

thyroid gland is composed of ____ cells that secrete and synthesize T4 and T3

Answer 5

follicular epithelial cells

Question 6

T4, T4, MIT and DIT remain bound to ___ while stored in follicles

Answer 6

Thyroglobulin

Question 7

normal outcome likely for hypothyroidism if treated by age

hypothyroidism after age ___ does not impact brain development

Answer 7

2wks

after age three does not impact brain development