Hyperlipidemias

Question 1

Type I: Hyperlipoproteinemia

Answer 1

• rare genetic disorder
• Lipoprotein Lipase def
• Apo C-II def
• elevated chylomicrons

Question 2

Type IIa: Familial Hypercholesterolemia

Answer 2

• common AD disorder
• LDL receptor def
• elevated LDL

Question 3

Type IIb : Famlial Combined Hyperlipo-proteinamia

Answer 3

• common AD disorder
• low LDL recptor to Apo B ratio
• Elevation of VLDL /LDL/TAGs

Question 4

Type III: Familial Dysbetalipoproteinemia

Answer 4

• rare
• apo E def
• elevated IDL (VLDL remnant)

Question 5

Type IV: Familial Hyperlipemia

Answer 5

• common
• VLDL overproduction w/ low clearance
• elevated VLDLs

Question 6

Type V: Hypertriglyseridemia w/ chylomicronemia

Answer 6

• uncommon
• VLDL overproduction w/ underproduction Lipoprotein lipase
• elevated VLDLs w/ chylomicrons