Guillain-Barre Syndrome Flashcards
1
Q
Guillain-Barre is the most common _____
A
-flaccid paralysis in developed countries
2
Q
GBS
A
-guillain barre syndrome
3
Q
GBS profile
A
- Men>women
- all ages and children
4
Q
GBS is an
A
- autoimmune disease effecting peripheral nerves
- loss of limb weakness and loss of DTRs
5
Q
GBS triggered by
A
-preceding bacterial or viral infection (60-70%)
6
Q
Most common pathogen involved
A
- Camplyobacter (C.) Jejuni
- causing gastroenteritis
7
Q
Immune Response
A
-infection w/ C Jejuni with ganglioside-like structure->ntibodies associated with C Jejuni attacks structures on peripheral axons–>axonal damage with influx of macrophages
8
Q
axonal degeneration causes
A
decreased conduction speed
9
Q
Temporal Pattern
A
- bacterial infection 1-3 weeks prior
- gradual symmetrical ascending paralysis (4 weeks with paresthesias and numbness
- Plateau (about 2 weeks)
- gradual resolution of paralysis (weeks-months)
- variable return to full function (20% left with disability)
10
Q
2 preceding viral infections
A
- cytomegalovirus
- haemophilus influenza
11
Q
diagnosis
A
- first ID which part of the NS involved
- EMG and Nerve conduction Velocity
- Lumbar Puncture
- Routine blood tests
- antiganglioside antibodies
12
Q
4 variants of GBS
A
- acute inflammatory demyelinating polyneuropathy (most common in US)
- acute motor axonal neuropathy
- acute motor and sensory axonal neuropathy
- Miller Fisher Syndrome
13
Q
Acure Inflammatory demyelinating Polyneuropathy
A
- AIDP
- most common form
- autoimmune disease with infection first
- typical demyelination-shwan cells
- EMG: Slowed NCV
14
Q
Symptoms of AIDP
A
- LE before UE
- distal and proximal Mm (cranial nerves too)
- sensory nerves involved
- DTRs absent
- Proximal pain/ache
- variable autonomic involvement
15
Q
AIDP Prognosis
A
- variable, depends on degree of axonal damage
- recovery may be slow and poor, or quick
- mortality rate in acute phase 3.5-12% (respiratory failure)
