Pathology

Question 1

What happens to K levels in erroneously haemolysed blood?

Answer 1

It increases

Question 2

What is APTT?

Answer 2

Activated partial thromboplastin time

Question 3

HER2 amplification can be found in which type of cancer?

Answer 3

Breast

Question 4

BRAF mutation can be found in which type of cancer?

Answer 4

Melanoma

Question 6

Which liver enzymes are cytoplasmic?

Answer 6

AST, ALT, LD

Question 7

Which liver enzymes are membrane bound?

Answer 7

ALP, GGT

Question 8

Which liver enzymes are in the mitochondria?

Answer 8

Mitochondrial AST

Question 9

What does enzyme induction refer to in regards to liver function tests?

Answer 9

Some drugs or alcohol induce increased production of liver enzymes causing elevated LFTs when only normal cell turnover is occurring

Eg Raised GGT due to alcohol induction

Question 10

Which is liver specific, ALT or AST?

Answer 10

ALT - think L for liver

Question 11

Which has a shorter half life, AST or ALT?

What are the implications?

Answer 11

AST is shorter (36hrs

to 12hrs) therefore, will be gone faster than ALT

There is more AST than ALT so AST will be higher early on

Question 12

Normal ALT in hep A infection?

Answer 12

2500-5000

Question 13

f