Diagnostics

Question 1

CGH microarray

Answer 1

Useful for comparing 1 genome to another.
Gives data regarding copy number variation
use: diagnosing developmental abnormalities
Detects smaller deletions or duplications than G-banding

Question 2

CGH microarray vs. G-banding

Answer 2

CGH can detect smaller deletions or duplications (better resolution)

G-banding- can detect balanced rearrangement

Question 3

SNP Chip

Answer 3

Can detect single nucleotide polymorphisms
May inform haplotype (particular arrangement of polymorphisms & alleles founds on a single chromosome)
May inform pharmacogenomics