4-2 Cell Wall and Protein Synthesis Ihibitors (dx)

Question 1

oral form of Penicillin

Answer 1

Penicllin V

Question 2

DOC for infections caused by –cocci and treponema pallidum

Answer 2

Penicillin G

Question 3

used mainly for OROPHARYNGEAL infections and minor infections

Answer 3

Penicillin V

Question 4

Repository form, given once a week IM

Answer 4

procaine

Question 5

resistant to staph Beta Lactamases

Answer 5

Methicilllin Nafcillin

Question 6

no longer used B-lactamase resistant d/t ATN adverse effect

Answer 6

methicillin

Question 7

more active against gram negative bacteria

Answer 7

EXTENDED spectrum penicillins

Question 8

acid stable and well absorbed

Answer 8

DAA - doxacillin, ampicillin, amoxicillin

Question 9

esp for shigellosis and not salmonellosis

Answer 9

ampicillin

Question 10

for pseudomonal infection outside urinary tract (prevents resistance)

Answer 10

anti pseudomonal pen + AG/Fluoroquinolones

Question 11

resistance to penicillins?

Answer 11

1. inactivationby beta lactamase
2. modification of target PBP’s
3. impaired penetration of drug to PBP’s
4. presence of an efflux pump

Question 12

modification of target PBPs example?

Answer 12

Methicillin by staph;

pen G by pneumo and strep

Question 13

all cocci are gram + except

Answer 13

nisseria and branhamella

Question 14

all bacilli are gram - excepet

Answer 14

clostridium, corynebacterium, bacillus, listeria

CCBL

Question 15

cephalosporins have broader spectrum of activity but not active against

Answer 15

enterococci

monocytogenes

Question 16

cephalosporins have same moa with?

Answer 16

penicillin

Question 17

resistance to cephalosporins?

Answer 17

1. decrease in membrane permeability

2. changes in PBP’s

Question 18

parenteral first gen cephalosporin; used as surgical prophylaxis

Answer 18

Cefazolin

Question 19

tubular secretory agent that increases serum levels of cephalosporin

Answer 19

probenecid

Question 20

cefoxitin, cefotetan, cefmetazole

Answer 20

tx for peritonitis

diverculitis; since they are good for anAEROBES

Question 21

for community acquired pneumonia; ONLY second gen that can cross BBB

Answer 21

CeFUROxime

Question 22

oral first line treatment for N. gonorrhea

Answer 22

cefixime

Question 23

treatment for P aeruginossa

Answer 23

dime and pera!! ceftazidime and cefoperazone

Question 24

for B. fragilis

Answer 24

OX!! moxalactam and ceftizOXime

Question 25

the methylthiotetrazole group present in these rx causes hypoprotrombinemia and bleeding

Answer 25

cefamandole; cefmetazole; cefotetam; cefoperazone