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Unit 6: Pathology > Viral Hepatitis > Flashcards

Viral Hepatitis Flashcards

1
Q

What are other causes of hepatitis besides hepatitis viruses?

A

EBV and CMV

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2
Q

Which type of bilirubin is increased in hepatitis?

A

both CB and UCB

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3
Q

How do you distinguish acute from chronic viral hepatitis?

A

chronic - symptoms last > 6 months

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4
Q

What is the appearance of the liver in acute hepatitis?

A

lobular disarray, liver cell death
central phelbitis, endophlebitis
councilman bodies

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5
Q

What are councilman bodies

A

pyknotic nucleus extruded from liver cells

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6
Q

Chronic hepatitis presents with a sepctrum of inflammation, name some types of these pathologies?

A
  1. focal periportal necrosis
  2. portal tract lesions - proliferation of bile ductules
  3. intralobular lesions
  4. periportal fibrosis
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7
Q

What is confluent hepatitis necrosis

A

death of hepatocytes in geographical distribution

affects whole regions of lobule

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8
Q

What is the most common cause of confluent hepatitis necrosis?

A

hep B

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9
Q

What is the method of transmission of each of the hepatitis viruses?

A

hep A and E - fecal oral

Hep B, C - parenteral

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10
Q

Which hepatitis virus is most common?

A

hep A

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11
Q

What are some prototypical types of people that acquire hep A?

A

travelers, MSM, day care children

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12
Q

What is the main source from which people contract hep E

A

contaminated water (uncercooked seafood)

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13
Q

What type of immunoglobulin indicates active infection?

A

IgM

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14
Q

What is the first serologic marker to rise in Hep B?

A

HbsAg

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15
Q

What defines the chronic state of HepB?

A

HbsAg present for >6 months

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16
Q

When is the core antibody present?

A

acute battle and window phase

17
Q

What is the sign of victory of beating hep B?

A

IgG production

18
Q

What does the presence of the envelop antigen indicate? when is it present?

A

infectivity

present during acute phase and can be present chronically

19
Q

What is the hep B vaccine composed of?

A

recombinant HBsAg

20
Q

What are some extrahepatic manifestations of the hep B virus?

A 
Ab-ag complex causes:
serum sickness 
polyarteritis
glomerulonephritis
cryoglobulinemia
21
Q

How do you confirm infection with hep C? how long would you need to wait

A

HCV RNA test

-can be detected within 2 weeks

22
Q

What indicates hep C recovery?

A

dec RNA levels

23
Q

What are some extrahepatic manifestations with hep c?

A
  1. mixed cryoglobulinemia –> systemic vasculitis
  2. membranoproliferative GN
  3. B cell non hodkin lymphomas
24
Q

What is the most common indication for a liver transplantation?

A

infection with hep C

25
Q

Hep D needs Hep B to infect, is superinfection or coinfection a more severe infection?

A

superinfection

Unit 6: Pathology (22 decks)

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