Parkinson's pharmacology

Question 0

Part of the basal ganglia where dopamine is synthesized

Answer 0

substantia nigra

Question 1

A form of secondary parkinson’s disease that is caused by a viral infection

Answer 1

postencephalitic parkinsonism

Question 2

DA receptors that are GPCRs that are generally excitatory

Answer 2

D1type (D1 and D5)

Question 3

The most effective treatment of parkinson’s disease

Answer 3

levodopa

Question 4

MOA of carbidopa

Answer 4

peripheral dopa decarboxylase inhibitor

Question 5

MOA of entacopone

Answer 5

inhibits COMT in periphery

Question 6

MOA of tolcapone

Answer 6

Inhibits COMT in periphery and CNS

Question 7

Major risk associated with tolcapone

Answer 7

hepatic failure

Question 9

Ergot D2-dopamine receptor agonist and partial D1 antagonist

Answer 9

Bromocriptine

Question 10

MAO-B inhibitor that is not metabolized to amphetamine

Answer 10

resagiline

Question 12

2 non-ergot D2 and D3 receptor agonists

Answer 12

Pramiprexole

Ropinirole

Question 13

A dopamine receptor antagonist that is a SQ injection that is indicated for the acute, intermittent treatment of hypomobility, “off” episodes in advanced PD

Answer 13

apomorphine (Apokyn)

Question 14

Anti-emetic therapy commonly used with apomorphine

Answer 14

trimethobenzamide

Question 15

Anti-viral agent that can also be used in PD because it increases DA release and blocks NMDA receptors

Answer 15

amantadine

Question 16

MAO-B inhibitor that has an amphetamine metabolite

Answer 16

selegiline

Question 20

DA receptors that are GPCRs that are generally inhibitory

Answer 20

D2 type (D2, D3 and D4)