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Haematology and Oncology - step > pathologic RBC forms > Flashcards

pathologic RBC forms Flashcards

1
Q

acanthocytes

A

liver disease
abetalipoproteinemia
states of cholesterol dysregulation

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2
Q

basophilic stippling

A

lead poisoning

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3
Q

degmacyte is what?

A

bite cell

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4
Q

degmacyte/bite cell

A

G6PD deficiency

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5
Q

elliptocyte

A

hereditary elliptocytosis

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6
Q

macro-ovalocyte

A 
megaloblastic anaemia (also wtih hypersegmented PMNs)
marrow failure
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7
Q

ringed sideroblasts

A

sideroblastic anaemia

excess Fe in mitochondria

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8
Q

schistocytes/helmet cell

A 
DIC
TTP
HUS
HELLP syndrome
mechanical hemolysis (heart valve prosthesis)
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9
Q

sickle cell

A

sickle cell anaemia

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10
Q

when do sickle cells sickle

A

dehydrated, deoxygenation, high altitude

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11
Q

spherocytes

A

hereditary spherocytosis

drug and infection induced hemolytic anaemia

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12
Q

what is a dacrocyte?

A

teardrop cell

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13
Q

dacrocyte vrs degmacyte

A

dacrocyte - teardrop - bone marrow infiltration, myelodibrosis
degmacyte - bite cell - G6Pd def

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14
Q

target cell

A 
HbC
asplenia
liver disease
thalassemia
HALT
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15
Q

liver disease

A

target cells and acanthocytes

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16
Q

abetalipoproteinemia

A

acanthocyte

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17
Q

cholesterol dysregulation

A

acanthocyte

18
Q

lead poisoning

A

basophilic stippling and sideroblast

19
Q

G6PD def

A

bite cells, degmacyte

20
Q

hereditary elliptocytosis

A

elliptocyte

21
Q

megaloblastic anaemia

A

macro-ovalovyte

\hypersegmented PMNs

22
Q

hypersegmented PMNs

A

megaloblastic anaemia

23
Q

marrow failure

A

macro-ovalocyte

24
Q

DIC, TTP/HUS, HELLP syndrome

A

shistocytes/helmet cell

25
Q

sickle cell disease

A

sickle cell

26
Q

hereditary spherocytosis

A

sperocyte

27
Q

drug induced hemolytic anaemia

A

spherocyte

28
Q

infection induced hemolytic anaemia

A

spherocyte

29
Q

bone marrow infiltration

A

dacrocyte/teardrop cell

30
Q

myelofibrosis

A

dacrocyte/teardrop cell

31
Q

HbC

A

target cell

32
Q

asplenia

A

target cell

33
Q

liver disease

A

target cell

acanthocytes

34
Q

thalaseeia

A

target cells

35
Q

what are heinz bodies

A

oxidation of Hb-SH groups to S-S = Hb precipitation

36
Q

what happens to heinz bodies

A

oxidized hb precipitated = phagocytic damage to RBC membrane - G6PD def = bite cells/degmacyte

37
Q

heinz body like inclusiosn ?

A

alpha thalassemia

38
Q

what are howell jolly bodies

A

basophilic nuclear remnants found in RBCs

39
Q

what is the fate of howell jollly bodies?

A

howell jolly bodies - nuclear remnants in RBCs are normally removed from RBCs by splenic macrophages

40
Q

where do you see howell jolly bodies

A

seen in patients with fucntional hyposlepina or asplenia

41
Q

functional hyposplenia or asplenia

A

howell jolly bodies

Haematology and Oncology - step (5 decks)

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