Tavalin's bullshit Flashcards
1
Q
Henderson-Hasselbalch equation
A
2
Q
Therpeutic window is
A
Maximum tolerable concentration - minimum effective concentration
3
Q
Advantages and disadvantages of oral administration
A
Advantages: safe, cheap
Disadvantages: Slow onset, patient noncompliance, low bioavailability (1st pass)
4
Q
Factors affecting GI absoprtion of drugs
A
- Acidic environment of stomach cna breakdown drugs
- Gastric emptying time
- Intestinal motility and transit time
5
Q
Volume distribution equation
A
6
Q
Who does Tavalin remind you of?
A
7
Q
Volume of extracellular fluid
A
13-16 L
8
Q
Volume of plasma
A
~4 L
9
Q
Volume of interstitial fluid
A
10-13 L
10
Q
Volume of intracellular fluid
A
25-28 L
11
Q
Total body water
A
40 L
12
Q
Phase I metbaolic reactions take place in
A
Endoplasmic reticulum
13
Q
Phase II metabolic reactions take place in
A
Cytosol
14
Q
Phase I reaction types
A
- Oxidation
- Reduction
- Hydrolysis
15
Q
Phase II reaction types
A
- Glucuronidation
- Acylation
- Sulfoxidation
- Glutathione conjugation
17
Q
Population distribution for genotypic polymorphisms
A
