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Microbiology > cytokines > Flashcards

cytokines Flashcards

1
Q

which cells produce IL-1 (alpha, beta)

A

macrophage, endothelial, dendritic, langerhans

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2
Q

what functions do IL-1 (alpha, beta) have?

A
  • stimulates IL-2 receptor emergence in T cells
  • enhances B cell activation
  • induces fever/IL-6
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3
Q

which cells produce IL-2?

A

Th1

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4
Q

what functions does IL-2 have?

A
  • T cell growth factor

- activates NK and B cells

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5
Q

which cells produce IL-3?

A

T cells

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6
Q

what does IL-3 do?

A

stimulates hematopoiesis

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7
Q

which cells produce IL-4?

A

T cells

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8
Q

what does IL-4 do?

A
  • stimulates synthesis of IgE

- down regulates IFN-g

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9
Q

what cells produce IL-5?

A

T cells

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10
Q

what does IL-5 do?

A
  • stimulates growth and differentiation of eosinophils
  • B cell growth factor
  • enhances IgA synthesis
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11
Q

which cells produce IL-6?

A

monocytes, T cells, endothelial cells

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12
Q

what does IL-6 do?

A

induces fever and late B cell differentiation

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13
Q

which cells produce IL-7?

A

bone marrow cells

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14
Q

what does IL-7 do?

A

stimulates pre B and pre T cells

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15
Q

which cells produce IL-8?

A

monocytes, endothelial cells, lymphocytes, fibroblasts

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16
Q

what does IL-8 do?

A

chemotactic factor for neutrophils and T cells

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17
Q

which cells produce IL-9?

A

Th cells

18
Q

what does IL-9 do?

A

T cell migration

19
Q

what cells produce IL-10?

A

Th2 cells

20
Q

what does IL-10 do?

A
  • inhibits IFN-g synthesis by Th1 cells

- cytokine suppressor

21
Q

what cells produce IL-11?

A

bone marrow

22
Q

what does IL-11 do?

A

stimulates hematopoesis

23
Q

what cells produce IL-12?

A

macrophages and B cells

24
Q

what does IL-12 do?

A
  • promotes Th1 differentiation and IFN-g synthesis
  • stimulates NK cells and CD8+ cells
  • works with IL-2
25
Q

which cells produce IL-13?

A

Th2 cells

26
Q

what does IL-13 do?

A

inhibits inflammatory cytokines (1, 6, 8, 10, MCP)

27
Q

which cells produce IL-15?

A

T cells

28
Q

what does IL-15 do?

A
  • T cell mitogen

- enhances growth of intestinal endothelium

29
Q

what cells produce IL-16?

A

CD8+ cells, eosinophils

30
Q

what does IL-16 do?

A
  • increases class II MHC, chemotaxis, and CD4+ cytokines

- decreases antigen induced proliferation

31
Q

what cells produce IL-17?

A

T cells

32
Q

what does IL-17 do?

A

enhances inflammatory response

33
Q

what cells produce IL-18?

A

activated macrophages

34
Q

what does IL-18 do?

A

increases IFN-g production and NK cells

35
Q

what cells produce TNF-a?

A

macrophages, T cells, B cells, large granular lymphocytes

36
Q

what does TNF-a do?

A
  • cytotoxic for tumors
  • causes cachexia
  • mediates bacterial shock
37
Q

what cells produce TNF-b?

A

T cells

38
Q

what does TNF-b do?

A

cytotoxic for tumors

39
Q

what cells produce transforming growth factor B?

A

almost all normal cells

40
Q

what does TGF-b do?

A
  • inhibits proliferation of B and T cells
  • reduces cytokine receptors
  • potent chemotactic agent for leukocytes
  • mediates inflammation and tissue repair

Microbiology (3 decks)

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