shockry-autacoids

Question 1

what are the two serotonin agonists?

Answer 1

cisapride

**fluoxetine **-prozac

Question 2

which serotonin agonist is a prokinetic and works through the entire GI tract?

Answer 2

cisapride

** **it is a 5-HT₄R agonist in enteric neurons

Question 3

what are the clinical uses of fluoxetine?

Answer 3

• txt of canine separation anxity
• txt of behavior disorders- aggression, OCD, anxiety
• can be used transdermal in cats
• use with cats that have elimination and urine making probs

Question 4

what is the MOA of fluoxetine?

Answer 4

increase serotonin levels in the brain (improves signs of depression in human)

it is a Serotonin specific reuptake inhibitor (SSRI) so it wont break down and will stay around longer

Question 5

what are the serotonin antagnosists?

Answer 5

• cyproheptadine
• ondansetron
• metoclopramide
• mirtazapine

Question 6

what serotinin antagonist can be used to t_xt serotonin syndrome_ and stimulate appetite in small animals

Answer 6

cyproheptadine

it blockes H1 and serotonin R which inhibits ACTH

Question 7

what serotonin antagonist is prevention and txt of anticancer chemotherapy-induce nausea and vom?

Answer 7

Ondansetron

MOA: 5HT receptor antagonist (central and peripheral)

Question 8

at a high dose this 5HT receptor antagonist can be used as an anti-emetic centrally

Answer 8

metoclopramide

Question 9

at a low dose this _D1 & D2 receptor antagnos_t can be used a prokinetic peripherally

Answer 9

metoclopramide

Question 10

which serotonin antagonist is a TCA antidepressant and an anti-emetic

Answer 10

mirtazapine

Question 11

what drug blocks NK1 receptors preventing substace P form binding resulting in an anti-emeic effect?

Answer 11

Maropitant

classified as a neurokinin antagonist

prevents vom due to motion sickness as well as vom due to viral infx

Question 12

what can inhibit secretionof renin?

Answer 12

• Ang 2
• ADH
• hypertension
• increased reabsorption of Na
• B1-adrenergic blockers

Question 13

what **stimulates secretion **of renin?

Answer 13

• hypotension
• decreased renal blood flow
• low Na or Cl in blood
• sympathetic stim

Question 14

**angiotensin II ** stimulates _____secretion and inhibits _____ release.

Answer 14

stimulates ALD secretion

inhibits r_enin release_

Question 15

what PG agonist is a synthetic PGE₁that is used as an anti-ulcer txt?

Answer 15

misoprostol

Question 16

what are the PG agonists that increase uveoscleral outflow by stimulting FP receptors?

Answer 16

• Latanoprost
• travopost
• bimatoprost

they are topical txt for open-angle glaucome/ocular hypertension

Question 17

What are the PG inhibitors?

Answer 17

• COX inhibitors (NSAIDS)
• Phospholipase A2 inhibitors (corticosteroids also inhibit COX2)

Question 18

what are the two Leukotriene inhibitors?

Answer 18

• zafirlukast
• zileuton

Question 19

what leukotriene receptor antagonist prevents bronchoconstriction in cats?

Answer 19

zafirlukast

LOX already made, just block R

Question 20

which drug is a 5-Lipoxygenase inhibitor and prevents bronchoconstriction in cats?

Answer 20

zileuton

it inhibits leukotriene formation

Question 21

WTF is oclacitinib and what is it used for?

Answer 21

• janus kinase inhibitor
• use for control of puritis associated allergic and atopic dermatitis