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HRM - Pharmacology > Diabetes Class Mechanisms > Flashcards

Diabetes Class Mechanisms Flashcards

1
Q

Insulin

A

Binds insulin receptor, increase glucose uptake

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2
Q

Biguanides

A

Decrease gluconeogenesis
Increase glycolysis
Increase glucose uptake

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3
Q

Sulfonylureas

A
  1. Close K channel in beta cell membrane
  2. Depolarize cell
  3. Release insulin by increased Ca influx
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4
Q

Glitazone/Thiazolidinediones

A

Increase insulin sensitivity in peripheral tissue via PPAR-gamma transcription regulator

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5
Q

GLP-1 analogs

A

Increase insulin

Decrease glucagon

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6
Q

DPP-4 inhibitors

A

Increase insulin

Decrease glucagon

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7
Q

Amylin analogs

A

Decrease gastric emptying

Decrease glucagon

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8
Q

SGLT-2 inhibitors

A

Blocks glucose reabsorption in PCT

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9
Q

Alpha glucosidase inhibtors

A

Inhibit intestinal brush-border alpha-glucosidases, decreasing glucose absorption

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10
Q

Metglitinides

A

Increase insulin

Decrease glucagon

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HRM - Pharmacology (12 decks)

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