Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

B&B Part II > CSF/CNS Infections > Flashcards

CSF/CNS Infections Flashcards

1
Q

Produced by-

Volume in

  • Neonates-
  • Adults-

Rate of Formation

Turnover

A

Choroid Plexus

  • 10-60 mL
  • 90-150 mL

500 mL/Day

Every 5-7 Hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

______ cells line the ventricles and play a role in transporting components of CSF into the ventricles

A

Ependymal Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ependymal cells are a type of ____ cell

A

Glial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CSF fluid forms in two steps

1)

2)

A

1) Fenestration of capillaries delivers ultrafiltered plasma
2) Ependymal cells transport AA and protein components into vesicles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Capillary plasma ultrafiltrate is ____ blood/brain barrier

A

outside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

These four substances are found in significantly lower concentrations in the CSF vs. Plasma

A

K+, Glucose, AA, and Proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

______ move excess CSF from subarachnoid space to venous sinuses via transcytosis

A

Arachnoid Granulations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CSF is absorbed into the venous blood supply of the _____

A

Superior Sagital Sinus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Small Envaginations- Arachnoid ____

Large Envaginations- Arachnoid _____

A
  • Villi
  • Granulations
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Three features of the blood/brain barrier

A
  1. Non-fenestrated (use tight junctions)
  2. Thick basement membrane
  3. Astrocyte endfeet surround the capillar
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cannot cross blood/brain barrier

A

Large, charged molecules

  • Fibrinogen, Prealbumin

Drugs (some)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Readily cross Blood/Brain Barrier

A

Uncharged Molecules

Lipids

Oxygen

Caffeine, Nicotine, Ethanol, Heroin

Water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Lumbar Punctures should be performed at the level of

A

L3/L4 or L4/L5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Contraindications of LP

A

Increased Cranial Pressure bc this can cause cerebral herniation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Lumbar Puncture Complication

A

Headache in 10-30% of patients

Caused by decreased support of brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

LP Collection

A

20 mL, in 3-4 tubes

17
Q

CNS Pathologies

Normal

Cloudy

Bloody

Orange/Brown

Viscous

A

Normal- Clear, Colorless, Water

Cloudy- High white count due to CNS infection

Bloody- Trauma from procedure or sub-arachnoid hemorrhage

Orange/Brown- Increased Carotene intake or metastic melanoma

Viscous- Metastic Mucinous Adenocarcinoma

18
Q

Pleocytosis

A

Increased cell counts in CSF (indicated CNS infection)

19
Q

Normal CSF Cell Counts

White

Red

A

1-5 Cells/microliter

0 cells per microliter

20
Q

Normal CNS is mostly lymphocytes (40-80%), with few monocytes and neutrophils

Elevated Neutrophils indicate

Elevated Lymphocytes indicate

A

Elevated Neutrophils indicate Bacterial Infection

Elevated Lymphocytes indicate Viral Infection

21
Q

CSF Glucuse usually goes ____

Caused by _____ not _____ themselves

A

CSF Glucuse usually goes down

Caused by increased brain anaerobic activity, not bacteria themselves

22
Q

Three Reasons for increased CSF Proteins

A

Increased permeability at barriers (blood-brain-barrier, blood-CSF barrier)
Decreased reabsorbtion at arachnoid granules
increased production of immunoglobulins

23
Q

Latex Agglutination Antibody Test

A

Looks for specific pathogens like strep pneumo or cryptococcus

  • checks to see if CSF sample has antigen which clump onto antibodies
24
Q

Bacterial Meningitis in Neonates

A

GEL

  • G*roup B Strep
  • E.*Coli
  • L*isteria monocytogenes
25
Q

Bacterial Meningitis in Adults

A

SHiN

Strep Pneumo

H.Influeza

Neisseria meningitidis

26
Q

Bacterial Meningitis in Immunocompromised

A

Strep Pneumo

Listeria monocytogenes

27
Q

Viral Meningitis (Example, Spread)

Enterovirus

HSV

Arboviruses

A

Enterovirus - Fecal-Oral, mostly in kids

HSV- Direct skin contact (less common than enterovirus, but worse symptoms)

Arboviruses (WNV, spread by mosquitos and ticks)

28
Q

HIV Associated Meningitis

Fungal- CCH

Bacterial- TaBLeS

Viral - CV

A

Funcal- Cryptococcosis neoformans, Coccidioides immitis (Valley Fever), Histoplasma capsulatum (Cave Disease)

Bacterial- TB, Sphyllis, Listeria

Viral- CMV, VSV

B&B Part II (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions