ED Flashcards

1
Q

What are the four systems necessary for a normal erection

A

Vascular
Nervous
Hormonal
Psychological

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2
Q

What are chronic medical conditions associated with ED

A
HTN
DM
prostate issues
Coronary & peripheral vascular disease
Neurologic disorders
Endocrine disorders
Psychiatric disorders
Dyslipidemia
Renal failure
Liver disease
Penile disease
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3
Q

What medication classes are associated with ED

A
antihypertensives
lipid meds
antidepressants
Histamine antagonist
antipsychotics
anticonvulsants
antiandrogens
Recreational drugs
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4
Q

What is general approach to treating ED

A

identify and reverse underlying cause
assess ability to perform sexual activity
consider partner issues

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5
Q

What are MOA, AE and CI for Phosphodiesterase Type 5 inhibitors with ED

A

MOA:
inhibit cGMP breakdown by PDE5, so NO/cGMP can aid in erection

AE:
HA
facial flusing
dyspepsia
nasal congestion
dizziness
abnormal vision
prolonged or priapism erections
decrease BP
optic neuropathy issues
CI:
Nitrates
alpha-blockers
high CV risk
sickle cell anemia
multiple myeloma
leukemia
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6
Q

What are MOA, dosing, AE and CI for Alprostadil with ED

A

MOA:
stimulate adenyl cyclase and that increases cAMP

DOSE:
Caverject 1.25 - 60 mcg 5-10 min before sex
Muse (urethral) 125 - 1000 mcg 5-10 min before sex

AE:
local pain
syncope
dizziness
priapism
fibrotic reaction
CI:
priapism
sickle cell anemia
anticoagulants
bleeding disorders
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7
Q

What are AE and CI for testosterone with ED

A
AE:
gynecomastia
dyslipidemia
polychthemia
acne
weight gain
HTN
edema
HF

CI:
prostate cancer
breast cancer
BPH

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