11 - osteoarthritis Flashcards
1
Q
OA - pathologic process of cartilage degeneration
DJD encompaases all the changes seen in OA
OA seen more commonly in dogs than cats
A
2
Q
A
3
Q
A
4
Q
- what two things promote degradative cartilage enzyme production
- what two things are associated with ^ proteoglycan synth?
A
- IL-1 and TNF-alpha
- TGF-alpha and IL-6
5
Q
clinical signs
- morning stiffness that improves with gentle exercise
- lameness is worse after heavy exercise
A
6
Q
A
7
Q
(tx)
- use NSAIDS
COX-2 selective are better
why are NSAIDs good?
A
- reduce prostaglandin production, decrease pain and inflammation
