Sartans

Question 1

List the Sartans.

Answer 1

Candesartan (Atacand)
Eprosartan (Teveten)
Irbesartan (Avapro, Karvea)
Losartan (Cozavan, cozaar)
Olmesartan (Olmetec)
Telmisartan (Micardis)
Valsartan (Diovan)

Question 2

What is the mode of action of Sartans?

Answer 2

> competitively block binding of angiotensin II to type 1 angiotensin (AT1) receptors
> reduce angiotensin-induced:
- vasoconstriction
- sodium reabsorption
- aldosterone release

Question 3

What are the indications of Sartans?

Answer 3

• HTN

- HF in patients unable to tolerate ACEI

Question 4

What are the AEs of Sartans?

Answer 4

Common

• dizziness
• headache
• hyperkalaemia

Infrequent

• first dose hypotension
• abnormal liver function
• muscle cramp, myalgia
• renal impairment

Rare

• cough
• angioedema

Question 5

What are the counseling points of Sartans?

Answer 5

• you may feel dizzy when you start taking this medicine. Get up gradually from sitting or lying to minimise this effect; sit or lie down if you become dizzy or light-headed
• don’t take potassium supplements while you are taking this medicine unless your doctor tells you to

Question 6

What do you monitor with Sartans?

Answer 6

• renal function (b4 tx)
• electrolytes (b4 tx)
• BP

Question 7

What are the dose ranges of Sartans?

Answer 7

Candesartan (Atacand):
4-32mg d

Olmesartan (Olmetec):
20-40mg d

Telmisartan (Micardis):
40-80mg d

Valsartan:
80-320mg d

Irbesartan (Avapro, Karvea):
75-300mg d