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Mattias - Dermatology > Deck 1 > Flashcards

Deck 1 Flashcards

1
Q

What is the cytotoxin causing necrotising fasciitis? What organism?

A

Panton Valentine Leukocidin (PVL)

Produced by virulent Staphlococcus Aureus (MRSA)

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2
Q

What does the virulence factor Adhesin do

A

Enables binding of the organism to host tissue

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3
Q

What does the virulence factor Invasin do

A

Enables the organism to invade host tissue

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4
Q

What does the virulence factor Impedin do

A

enables the organism to avoid host defense mechanism

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5
Q

What does the virulence factor Aggressin do

A

Causes damage to host directly

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6
Q

What does the virulence factor Modulin do

A

Induces damage to host indirectly

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7
Q

What is Erythropoietic protoporphyria

A

Disease presented in early childhood with discomfort, itch or tingling in sun exposed skin but other there are no clinical signs. It is caused by a build-up of protoporphyrin IX due to lack of the enzyme ferrochelatase.

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8
Q

What is porphyria cutanea tarda

A

Disease presented usually in iddle age with blistering, scarring and milia formation of dorsal hands/forearm and often hypertrichosis (excess hair). It is caused by a deficiency of the enzyme Uroporphyrinogen decarboxylase and can be associated with liver disease. Ex Alcoholics

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9
Q

What is a sign of Neurofibromatosis Type 1

A

Cafe au lait macules, 90% cases

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10
Q

Describe Plaque

A

Palpable flat lesion, >1cm. Raised or not

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11
Q

Describe Bulla

A

Fluid-filled blister, >1cm, Single compartment of multiloculated

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12
Q

Describe Papule

A

Small Palbable lesion, <1cm, Raised, solitary or multiple

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13
Q

Describe Pustule

A

Pus filled, white or yellow

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14
Q

Describe Nodule

A

A enlarged papule in three dimensions, >1cm, Solid

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15
Q

Describe Wheal

A

Oedematous papule or plaque caused by swelling in the dermis

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16
Q

Describe Vesicle (dermatology skin lesion)

A

Small fluid filled blister, <1cm, single or multiple, clear or blood strained

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17
Q

Describe Macule

A

Small area of color change <1.5cm, smooth surface

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18
Q

Describe Maceration

A

Moist peeling skin

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19
Q

What organism usually cause impetigo

A

Staph. Aureus

20
Q

Tinea capitis affect the

A

Scalp

21
Q

Tinea barbae affect the

A

Beard

22
Q

Tinea corporis affect the

A

Body

23
Q

Tinea manuum affect the

A

Hand

24
Q

Tinea unguium affect the

A

Nails

25
Q

Tinea cruris affect the

A

Groin

26
Q

Tinea pedis affect the

A

Foot

27
Q

Which strain of HPV are most common in warts/veruca

A

Types 1-4

28
Q

Which strain of HPV are responsible for genital warts

A

Types 6 and 11

29
Q

Which strain of HPV are associated with cervical cancer

A

Types 16 and 18

30
Q

What is Actinic keratosis

A

Dry scaly patches of skin caused by damage from years of sun exposure

31
Q

What can Actinic keratosis develop into

A

Squamous cell carcinoma

32
Q

What is Bowen’s disease

A

A very early form of skin cancer which is very easily curable

33
Q

What type of cancer does Bowen’s disease turn into

A

Squamous cell carcinoma

34
Q

What is characteristic of Basal cell carcinoma

A

Rolled, pearly edges and Telangiectasias

35
Q

What is Telangiectasia

A

Small dilated blood vessels near the surface of the skin

36
Q

What disease is Dermatitis Herpetiformis associated with

A

Coeliac disease

37
Q

Features of Dermatitis Herpetiformis

A

Itchy, vesicular skin lesions on the extensor surfaces

38
Q

What is the pathologu of Dermatitis Herpetiformis

A

Autoimmune, deposition of IgA in the dermis

39
Q

What type of Psoriasis is classically preceeded by a Strep sore throat

A

Guttate psoriasis

40
Q

Features of Guttae psoriasis

A

Tear drop scaly papules on the trunk and the limbs

41
Q

Where is Lichen Planus typically seen

A

On the vulva of elderly women

42
Q

Features of Lichen Sclerosus

A

Itchy white spots

43
Q

Features of Lichen Planus

A 
The "P"s
Purple
Puritic
Papular
Polygonal
44
Q

First line treatment of Impetigo

A

Topical fusidic acid

45
Q

Second line treatment of Impetigo

A

Oral Flucloxacillin

Mattias - Dermatology (2 decks)

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