Opsonization Flashcards
what are the 2 primary opsonins
IgG
Complement factor C3
a hydrophillic or hydrophobic Ag surface would more easily be digested by a macrophage
hydrophobic
what is the difference b/w the Fab and Fc region on an Ig
Fab region recognizes Ag/microbe
Fc region recognizes self
what is the receptor for the Fc fragment of IgG
gamma
what is the receptor for the Fc fragement of IGE, what about IgA
Epsilon
Alpha
what are the 3 classes of IgG receptors
Fc(gamma)RI - CD 64
Fc(gamma)RII - CD 32
Fc(gamma)RIII - CD16
if a nuetrophil can not kill an Ag by itself, it can display a “death signal” which tells macrophages to phagocytize itself and the Ag (committing suicide). What is this death signal
Loss of the CD16 “bright” peak
what Fc(gamma) receptor is most important for phagocytosis of IgG coated microbes
RII
how many types of complement receptors are there for complement opsoninization
4 (all fragments of C3)
what are the chemotactic complement factors
C3a and C5a
what are the main complement derived opsonins
C3b and C3bi
what are the major phagocytic cells of the innate immune response
neutrophils
what is the difference b/w a monocyte and macrophages
when monocyte moves into tissue from the circulation now called macrophage
what is the function of monocytes/macrophages
- phagocytosis
- cytokine prod.
what are the 4 factors that increase polymorphonuclear cells (nuetrophils) or PMN’s
stress
injury
infection
increase in cytokines
