Exam 2 Flashcards

0
Q

the major signal sequence in Mitochondrial Amphiphilic alpha helix

A

Cytochrome oxidase subunit 4

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1
Q

amphiphilic alpha helix is formed from?

A

N terminal and internal signal sequences in the Mitochondria

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2
Q

TIM 22 and 23 complexes are localized in which mitochondrial compartment?

A

the inner mitochondrial membrane and extend into intermembrane space.

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3
Q

TOM complexes are present in? function?

A

outer membrane of the mitochondria.

import all nucleus encoded proteins

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4
Q

protein import into mitochondrial matrix is inserted into the membrane by?

A

TOM complex

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5
Q

TOM transports protein across the which membranes?

A

outer to inner membrane space.

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6
Q

in the inner membrane space, the protein binds to this complex and allows to move through the channel to the matrix

A

TIM complex

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7
Q

ATP strips off these molecules in protein transport into M. matrix

A

cytosolic heat shock protein chaperones

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8
Q

why does it go through the TOM and then the SAM complex?

A

the recognition process and the pulling in process. then the insertion process by SAM.

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9
Q

the second sequence is hydrophobic. T/F?

A

true. allows it to stick to the inner membrane space

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10
Q

the hydrophobic sequence is recognized on the second sequence by?

A

the OXA complex

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11
Q

Mia 40 forms what kind of bonds from the incoming protein to the intermembrane space?

A

disulfide bonds with abundant Cysteine residues on them.

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12
Q

ATP, ADP, and Phosphate transporters got though which complex?

A

TIM 22 complex

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13
Q

Pancreatic cells have a lot of?

A

rough ER for protein synthesis

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14
Q

the red thingy is the ER sequence…..

A

….

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15
Q

rough microsomes have a high density and stop sedementing in the centrifuge and float at ?

A

high sucrose concentrations

16
Q

ER signal sequences guided to ER membrane by 2 components

A

Signal recognition particle (SRP) and the SRP receptor

17
Q

SRP is made of 6 different polypeptides and bound to an ____ backbone molecule

A

RNA

18
Q

SRP is rod shaped with large hydrophobic pockets lined with?

A

Methionine amino acids

19
Q

the core of the translocator is filled with a water filled pore made up of?

A

Sec ….

20
Q

signal sequne interacts with the specific site within the closed pore plug to open it…

A

……

21
Q

translocation of a soluble portein. peptidase cleaves off NH signal sequcen

A

…..