Monobactams and Glycopeptides

Question 1

Aztreonam-Azactam (monobactam)

Answer 1

beta lactam ring, ADE similar to penicillins

Question 2

Vancomycin (glycopeptide)

Answer 2

inhibits cell wall at a step earlier than beta-lactams

Question 3

Vancomycin Kinetics

Answer 3

poorly absorbed, oral for C. difficile, IV for systemic infections, widely distributed, limited CNS

Question 4

Vanco Adverse Reactions

Answer 4

flushing due to histamine release, rash, hives, itching, ototoxicity, chills, fever, neutropenia

Question 5

Telavancin-Vibativ (lipoglycopeptide)

Answer 5

MOA: same as vanco, conc. dependent, Gram (+) MRSA and entero