General and Local Anesthetics - Kinder Flashcards
5 effects of general anesthesia
1 - unconscious 2 - amnesia 3 - analgesia 4 - inhibit autonomic reflexes 5 - skeletal m relax
balanced anesthesia
balance IV and inhaled drugs
volatile
liquid room temp
- admin with vaporizer
halothane, enflrane, isoflurane, desflurane, sevoflurane
-ane
gaseous
gas at room temp
NO
inhaled uptake and distribution
two factors - controlled by anesthesiologist
1 inspirited concentration
2 alveolar ventilation
Fa/Fi
PP in alveoli
Fa - alveolar concentration
Fi - inspired concentration
approaches 1 - faster anesthesia occuring
-equilibrium of inspired : alveolar
blood:gas partition coefficient
affinity of anesthetic for blood
low - rapid
high - slow
speed recovery
hyperventilation
-only way to alter elminiation by anesthesiologist
MAC
minimum alveolar concentration
-volume % that is anesthetic
1 MAC - 50% population immobile
1.3 MAC - 90%
four stages of CNS depression
1 - analgesia
2 - excitement - delirious
3 - surgical anesthesia - slow RR HR
4 - medullary depression - need to be ventilated
four planes of surgical anesthesia
ocular movement
eye reflexes
pupil size
increasing depth of anesthesia
hepatitis
halothane
malignant hypethermia
RyR receptor
-with inhaled anesthetics
tx - dantrolene
propofol MOA
potentiate Cl current through GABA complex
lipid
propofol ADR
egg allergy