Pregnancy & Cystic Fibrosis

Question 1

Amniotic fluid (AF)

Answer 1

regulates fetus temp, allows fetus movement, serves as influx & efflux of constituents for fetus

Question 2

Amniocentesis

Answer 2

drawing out the amniotic fluid via ultrasonograph
tests:
congenital diseases
neural tube defects
HDFN
fetal pulmonary disease

Question 3

how far along before amniocentesis?

Answer 3

25-26 weeks

only go before that if fearful of a congenital disease & want to abort

Question 4

Neural Tube defects

Answer 4

test mother for AFP, hCG, unconjugated estriol, & inhibin A
acetyl cholinesterase (AChE)
infant should swallow & metabolize AFP, when they do not see an increased AFP in AF & in mother's serum

Question 5

Acetyal Cholinesterase indicates?

Answer 5

indicates infant has spina bifida or open spine

Question 6

Fetal Lung maturity

Answer 6

need surfactant or else alveoli sacs will collapse & not open again due to increased surface tension

Question 7

fetal lung development by 24th week

Answer 7

type I cells
type II cells
as lung matures see increased PG, lecithin

Question 8

type I cells

Answer 8

form alveolar capillary membrane for gas exchange

Question 9

Type II cells

Answer 9

produce & store surfactant needed for alveolar stability and form lamellar bodies

Question 10

L/S ratio

Answer 10

‘gold standard’ for fetal lung maturity
lecithin/sphingomyelin ratio based on sphingomyelin raises slow & lecithin increases as lung mature
>2.0

Question 11

PG

Answer 11

phosphatidylglycerol or PG & lecithin compared to sphingomyelin levels
immunoassays

Question 12

Fluorescence Polarization

Answer 12

fluorescent dye combinded w/ albumin & surfactant in the AF
albumin stays constant so increase is due to surfactant

Question 13

Lamellar Body Count

Answer 13

newest & most commonly used
use platelet analyzer
as lungs mature, the lamellar bodies increase
30k-40k = mature lung

Question 14

Cystic Fibrosis

Answer 14

autosomal recessive disorder that affects the exocrine glands & causes electrolyte & mucous secretion abnormalities
primary cause of deaeth is pneumonia, secondary to heavy abnormal viscous mucus in lungs leading to blockages & pancreatic insufficiency

Question 15

testing

Answer 15

chromosome 7 CFTR mutation- does not move chloride ions causing sticky mucus to build up on the outside of the cell
sweat test