[OS 214 Exam 1] Lec 08: Viral Hepatitis Flashcards
What are the viral causes of hepatitis apart from the hepatotropic viruses?
EBV, CMV, Yellow fever virus
What are the modes of transmission of the hepatotropic viruses?
Hep A: food-borne, no chronic phase
Hep B and C: Vertical transmission, transfusion, sexual contact
What is the mean incubation period in Hep A?
30 days
What are the usual modes of transmission of the hepatotropic viruses?
Hep A: food-borne, no chronic phase
Hep B and C: Vertical transmission, transfusion, sexual contact
What are the possible complications of Hep
A?
fulminant hepatitis, cholestatic hepatitis, relapsing hepatitis
What is the main mode of transmission of HAV?
fecal-oral route
When does ALT peak in HAV infection?
4 weeks after infection
What are the implications of a rise in IgG levels in HAV infection?
convalescence or patient immunity
What is the treatment for HAV infection?
supportive therapy
What are the epidemiological features of HEV infection?
associated with fecally-contaminated drinking water, minimal person-to-person transmission
What is the average incubation period of HEV?
40 days
How is HEV infection different from HAV?
HEV: no viremia (stool is used to check for viral antigens),
blood is used for antibody detection
How long does IgM and IgG persist in HEV infection?
IgM: 3-4 months
IgG: lifetime
What is the CDC criteria for testing acute phase sera (IgE)?
discrete onset w/ jaundice OR serum ALT > 2.5x normal AND HAV IgM negative, HBV core IgM negative, HCV Ab negative
What is the most characteristic feature of HCV infection?
elevation of serum ALT in a fluctuating pattern
